Evidence map›Paper›PMID 30031041›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2018

Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics.

Emily D Wallace, Nicholas H Oberlies, Nadja B Cech, Joshua J Kellogg

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

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  11. Quality Consistency of Herbal Products: Chemical Evaluation.Progress in the chemistry of organic natural products · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Emily D WallaceDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, NC, 27402, USA. Electronic address: edwallac@uncg.edu.
Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, NC, 27402, USA. Electronic address: nicholas_oberlies@uncg.edu.
Nadja B CechDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, NC, 27402, USA. Electronic address: nbcech@uncg.edu.
Joshua J KelloggDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, NC, 27402, USA. Electronic address: jjkellog@uncg.edu.
University of North Carolina at Greensboro · US

Funding

Pharmacology CoreU54AT008909 · NCCIH · WASHINGTON STATE UNIVERSITY · PI BOYCE, RICHARD DAVID · 2015 to 2024
$22.4M
NCCIH NIH HHS U54 AT008909
6 · The paper itself

Abstract

Current estimates report that approximately 25% of U.S. adults use dietary supplements for medicinal purposes. Yet, regulation and transparency within the dietary supplement industry remains a challenge, and economic incentives encourage adulteration or augmentation of botanical dietary supplement products. Undisclosed changes to the dietary supplement composition could impact safety and efficacy; thus, there is a continued need to monitor possible botanical adulteration or mis-identification. Goldenseal, Hydrastis canadensis L. (Ranunculaceae), is a well-known botanical used to combat bacterial infections and digestive problems and is widely available as a dietary supplement. The goal of this study was to evaluate potential adulteration in commercial botanical products using untargeted metabolomics, with H. canadensis supplements serving as a test case. An untargeted ultraperformance liquid chromatography-mass spectrometry (LC-MS) metabolomics analysis was performed on 35 H. canadensis commercial products. Visual inspection of the chemometric data via principal component analysis (PCA) revealed several products that were distinct from the main groupings of samples, and subsequent evaluation of contributing metabolites led to their confirmation of the outliers as originating from a non-goldenseal species or a mixture of plant materials. The obtained results demonstrate the potential for untargeted metabolomics to discriminate between multiple unknown products and predict possible adulteration.

Indexed as

Drug ContaminationMetabolomicsChromatography, LiquidDatasets as TopicDietary SupplementsHydrastisMass SpectrometryPrincipal Component AnalysisReference StandardsAdulterationDietary supplementsGoldensealMass spectrometryMetabolomics

Identifiers

PMID30031041
PMCPMC6434943
OpenAlexW2884492414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.