Evidence map›Paper›PMID 30030914›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2018

Circulating Long Noncoding RNA LIPCAR Acts as a Novel Biomarker in Patients with ST-Segment Elevation Myocardial Infarction.

Meng Li, Yue-Feng Wang, Xin-Chun Yang, Li Xu, Wei-Ming Li, Kun Xia, Da-Peng Zhang, Ri-Na Wu, Tian Gan

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In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. LncRNAs as Emerging Diagnostic Biomarkers for Cardiovascular Diseases: Evidence Synthesis Through Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
  3. Review
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  5. Emerging Roles of Long Non-Coding RNAs in Cardiovascular Diseases.Journal of cellular and molecular medicine · 2025
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  8. Human mtDNA-Encoded Long ncRNAs: Knotty Molecules and Complex Functions.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meng LiHeart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
Yue-Feng WangHeart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
Xin-Chun YangHeart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
Li XuHeart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
Wei-Ming LiHeart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
Kun XiaHeart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
Da-Peng ZhangHeart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
Ri-Na WuDepartment of Cardiology, Baotou Central Hospital, Baotou, Inner Mongolia, China (mainland).
Tian GanDepartment of Radiology, Baogang Hospital, Baotou, Inner Mongolia, China (mainland).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Long noncoding RNAs (lncRNAs) recently have been implicated in the pathological processes of cardiovascular diseases. In this study, LncRNADisease database and PubMed database were used to screen myocardial infraction (MI)-related lncRNAs and to investigate the diagnostic role of lncRNAs in ST-segment elevation myocardial infraction (STEMI). MATERIAL AND METHODS Forty-six patients with STEMI and 40 healthy controls were included in the study. Venous blood samples acquired at different time points and the expression levels of lncRNAs in plasma were measured by qRT-PCR. In addition, other blood samples were collected before and after percutaneous coronary intervention (PCI). Correlation analysis and receiver operating characteristic (ROC) curve were used to assess the diagnosis value of the markers. All included patients were followed up for 12±1 months. RESULTS Nine MI-related lncRNAs were selected from the database. The qRT-PCR results showed that the expression of hypoxia inducible factor 1A antisense RNA 2 (aHIF), member 1 opposite strand/antisense transcript 1 (KCNQ1OT1), and mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) were significantly increased in patients with STEMI compared to the control patients. The ROC curve showed that LIPCAR (AUC=0.782, 95% CI: 0.707-0.0.894) had better diagnostic accuracy. Moreover, correlation analysis indicated that LIPCAR were positively correlated with myocardial enzymes and negatively correlated with left ventricular ejection fraction. The level of LIPCAR in STEMI patients after PCI was lower (P<0.05). Multivariate regression analysis indicated that higher levels of LIPCAR were independent predictors of major adverse cardiovascular events in patients with STEMI (HR=5.93; 95% CI, 1.46-9.77; P=0.001). CONCLUSIONS Highly expressed LIPCAR in plasma may serve as a warning sign for the diagnosis of STEMI.

Indexed as

Percutaneous Coronary InterventionAgedAged, 80 and overBiomarkersCase-Control StudiesCell-Free Nucleic AcidsFemaleHumansMaleMiddle AgedMyocardial InfarctionPredictive Value of TestsRNA, Long NoncodingROC CurveST Elevation Myocardial InfarctionBiomarkersCell-Free Nucleic AcidsRNA, Long Noncoding

Identifiers

PMID30030914
PMCPMC6067052

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.