ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2019
MRI UTE-T2* shows high incidence of cartilage subsurface matrix changes 2 years after ACL reconstruction.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Molecular cartilage pathology following anterior cruciate ligament reconstruction: a systematic review of MRI studies.Frontiers in surgery · 2026Pooled it
- Evaluation of Pre-Operative Cartilage and Meniscus Ultrashort Echo Time T2* as Biomarkers of Long-Term Clinical Outcomes Following Anterior Cruciate Ligament Reconstruction.Journal of magnetic resonance imaging : JMRI · 2026Article
- Clinical applications of UTE-T2* in knee MRI.Skeletal radiology · 2026Review
- Posterior Horn Meniscus Centroid Position Is Altered Soon After Noncontact ACL Injury in Males and Females.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Fast 3D UTE in vivo TMagnetic resonance in medicine · 2026Article
- Articular Cartilage Arthrokinematics and Compositional Measurements With qMRI 1 to 2 Years After ACL Reconstruction With Meniscal Surgery.The American journal of sports medicine · 2025Article
- Magnetic resonance imaging of cruciate ligament disorders: current updates.EFORT open reviews · 2025Review
- Exploring the asynchronous changes of articular cartilage and osteochondral junction in knee osteoarthritis based on T2 mapping and ultrashort echo time imaging: a pilot study.Quantitative imaging in medicine and surgery · 2025Article
- Reproducibility of Quantitative Double-Echo Steady-State TJournal of magnetic resonance imaging : JMRI · 2025Article
- Article
- Posttraumatic osteoarthritis after athletic knee injury: A narrative review of diagnostic imaging strategies.PM & R : the journal of injury, function, and rehabilitation · 2025Review
- Baseline-to-loaded changes in regional tibial cartilage thickness, T1ρ and T2: Utilization of an MRI compatible loading device.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Quantitative susceptibility and T1Osteoarthritis and cartilage open · 2024Article
- Clinical validation of fully automated laminar knee cartilage transverse relaxation time (T2) analysis in anterior cruciate ligament (ACL)-injured knees- on behalf of the osteoarthritis (OA)-Bio consortium.Quantitative imaging in medicine and surgery · 2024Article
- A feasibility study of in vivo quantitative ultra-short echo time-MRI for detecting early cartilage degeneration.Insights into imaging · 2024Article
- Assessment of the sacroiliac joint in patients with axial spondyloarthritis via three-dimensional ultrashort echo time magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2024Article
- Tibial and femoral articular cartilage exhibit opposite outcomes for T1ρ and T2* relaxation times in response to acute compressive loading in healthy knees.Journal of biomechanics · 2024Article
- Ultrashort time-to-echo T2* and T2* relaxometry for evaluation of lumbar disc degeneration: a comparative study.BMC musculoskeletal disorders · 2022Article
- On the fat saturation effect in quantitative ultrashort TE MR imaging.Magnetic resonance in medicine · 2022Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Alteration of deep cartilage matrix has been observed following anterior cruciate ligament (ACL) injury, evidenced by elevated MRI UTE-T2* values measured in small, 2-D cartilage regions of interest. This Level I diagnostic study seeks to more thoroughly evaluate deep cartilage matrix changes to medial tibiofemoral UTE-T2* maps 2 years after ACL reconstruction and examine the relative utilities of 3-D compared to 2-D assessments of cartilage UTE-T2* maps. Thirty-eight ACL-reconstructed and 20 uninjured subjects underwent MRI UTE-T2* mapping. "Small" single mid-sagittal 2-D and larger 3-D "tread mark" regions of interest were manually segmented and found to be correlated in medial cartilage (r > 0.58, p < 0.005). 3-D analyses of UTE-T2* maps showed differences to medial tibial cartilage between ACL-reconstructed and uninjured subjects (p = 0.007) that were not detected by smaller 2-D regions (p > 0.46). Quantitative comparisons show 14/38 (37%) ACL-reconstructed subjects have values >2 standard deviations higher than uninjured controls. Among a subset of ACL-reconstructed subjects with no morphologic MRI evidence of medial tibiofemoral cartilage or meniscal pathology (n = 12), elevated UTE-T2* values in "small" 2-D femoral (p = 0.011), but not larger 3-D tread mark regions of interest (p > 0.13), were observed. These data show the utility of 2-D UTE-T2* assessments of mid-sagittal weight-bearing regions of medial femoral cartilage for identifying subclinical deep cartilage matrix changes 2 years after ACLR. Clinical Significance: Mid-sagittal single slice 2-D UTE-T2* mapping may be an efficient means to assess medial femoral cartilage for subsurface matrix changes early after ACL reconstruction while 3-D assessments provide additional sensitivity to changes in the medial tibial plateau. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:370-377, 2019.
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