ArticleAnnals of biomedical engineering2018
On the Significance of Systolic Flow Waveform on Aortic Valve Energy Loss.
Article in Annals of biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Analysis of Energy and Pressure in the Sinus with Different Blood Pressures after Bioprosthetic Aortic Valve Replacement.Annals of biomedical engineering · 2024Article
- 3D Characterization of the Aortic Valve and Aortic Arch in Bicuspid Aortic Valve Patients.Annals of biomedical engineering · 2024Article
- Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention.Nature reviews. Cardiology · 2024Review
- An In-Vitro Study of the Flow Past a Transcatheter Aortic Valve Using Time-Resolved 3D Particle Tracking.Annals of biomedical engineering · 2023Article
- The Influence of Aortic Valve Disease on Coronary Hemodynamics: A Computational Model-Based Study.Bioengineering (Basel, Switzerland) · 2023Article
- Effect of catheter ablation on the hemodynamics of the left atrium : Hemodynamics of ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022Article
- Article
- Gradient and pressure recovery of a self-expandable transcatheter aortic valve depends on ascending aorta size: In vitro study.JTCVS open · 2022Article
- Predictive Model for Thrombus Formation After Transcatheter Valve Replacement.Cardiovascular engineering and technology · 2021Article
- The hemodynamics of transcatheter aortic valves in transcatheter aortic valves.The Journal of thoracic and cardiovascular surgery · 2021Article
- Sinus Hemodynamics After Transcatheter Aortic Valve in Transcatheter Aortic Valve.The Annals of thoracic surgery · 2020Article
- Fetal Transcatheter Trileaflet Heart Valve Hemodynamics: Implications of Scaling on Valve Mechanics and Turbulence.Annals of biomedical engineering · 2020Article
- Impact of BASILICA on Sinus and Neo-Sinus Hemodynamics after Valve-in-Valve with and without Coronary Flow.Cardiovascular revascularization medicine : including molecular interventions · 2020Article
- In-vitro characterization of self-expandable textile transcatheter aortic valves.Journal of the mechanical behavior of biomedical materials · 2020Article
- Differences in Pressure Recovery Between Balloon Expandable and Self-expandable Transcatheter Aortic Valves.Annals of biomedical engineering · 2020Article
- A turbulence in vitro assessment of On-X and St Jude Medical prostheses.The Journal of thoracic and cardiovascular surgery · 2020Article
- Modeling of the Instantaneous Transvalvular Pressure Gradient in Aortic Stenosis.Annals of biomedical engineering · 2019Article
- Spatiotemporal Complexity of the Aortic Sinus Vortex as a Function of Leaflet Calcification.Annals of biomedical engineering · 2019Article
- Reduction of Pressure Gradient and Turbulence Using Vortex Generators in Prosthetic Heart Valves.Annals of biomedical engineering · 2019Article
- Sinus Hemodynamics Variation with Tilted Transcatheter Aortic Valve Deployments.Annals of biomedical engineering · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
This study aims to quantitatively and qualitatively assess energy dissipation in the aortic valve as a function of systolic aortic flow waveform representing pathologies where flow time-to-peak is delayed. A bioprosthetic valve was tested in the aortic position of a left-heart simulator under physiological pressure and flow conditions. The flow loop piston pump was programmed to generate three different flow waveforms each with a different peak time annotated as early peak (EP) with a rapid acceleration, mid peak (MP) and late peak (LP) with a rapid deceleration. Energy dissipation was calculated from flow and pressure measurements while sinus vorticity dynamics were evaluated using time-resolved planar particle image velocimetry. Average pressure gradients during systole are found 30.2 ± 0.19, 30.7 ± 0.25 and 32.9 ± 0.29 mmHg and average dissipation over systole is found 0.95 ± 0.026, 1.05 ± 0.034 and 1.25 ± 0.043 W for EP, MP and LP respectively. As systole's acceleration phase is slower, sinus vortices are more likely to form, necessitating more energy exchange from shear layers inducing more viscous dissipation. EP found in healthy individuals is superior in terms of reducing energy dissipation and increasing aortic valve efficiency. In the context of possible left ventricular dysfunction and aortic stenosis, this means that delayed time-to-peak in the aortic flow waveform seen is not compensatory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.