ArticleJournal of molecular neuroscience : MN2018
Over-Expressed FEZF1 Predicts a Poor Prognosis in Glioma and Promotes Glioma Cell Malignant Biological Properties by Regulating Akt-ERK Pathway.
Article in Journal of molecular neuroscience : MN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- RETRACTION: Chlorpyrifos Suppresses Neutrophil Extracellular Traps in Carp by Promoting Necroptosis and Inhibiting Respiratory Burst Caused by the PKC/MAPK Pathway.Oxidative medicine and cellular longevity · 2026Article
- LncRNA FEZF1-AS1 regulates the gene expression and alternative splicing associated with osteosarcoma.Journal of orthopaedic surgery and research · 2025Article
- MicroRNA-16 inhibits the growth and metastasis of human glioma cells via modulation of PI3K/AKT/mTOR signalling pathway.Archives of medical science : AMS · 2024Article
- Histone Modifications and Non-Coding RNAs: Mutual Epigenetic Regulation and Role in Pathogenesis.International journal of molecular sciences · 2022Review
- ERK inhibition in glioblastoma is associated with autophagy activation and tumorigenesis suppression.Journal of neuro-oncology · 2022Article
- The Transcription FactorCancers · 2021Article
- Linc00475 promotes the progression of glioma by regulating the miR-141-3p/YAP1 axis.Journal of cellular and molecular medicine · 2021Article
- Geniposide Alleviates Oxidative Stress of Mice With Depression-Like Behaviors by Upregulating Six3os1.Frontiers in cell and developmental biology · 2020Article
- FEZF1-AS1: a novel vital oncogenic lncRNA in multiple human malignancies.Bioscience reports · 2019Review
- MicroRNA-181 inhibits the proliferation, drug sensitivity and invasion of human glioma cells by targeting Selenoprotein K (SELK).American journal of translational research · 2019Article
- LncRNA FEZF1-AS1 Promotes TGF-Journal of ophthalmology · 2019Article
- Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway.Journal of Cancer · 2019Article
- Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis.Journal of neuro-oncology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
FEZ family zinc finger 1 (FEZF1) is an essential transcription factor during olfactory development. In gastrointestinal tumors, FEZF1 plays an oncogenic role through DNA demethylation. However, the role of FEZF1 in the prognosis of human glioma prognosis remains unclear. In this research, we discovered that FEZF1 was significantly increased in glioma tissues in contrast to normal brain tissues (NBTs; P < 0.05). Moreover, the expression of FEZF1 showed a significant correlation with Eastern Cooperative Oncology Group performance status, World Health Organization grade, isocitrate dehydrogenase 1 mutation, over-expression of glial fibrillary acidic protein and 1p19q co-deletion. Furthermore, a high level of FEZF1 in patients with glioma acted as an independent biomarker to predict reduced survival (P = 0.026). In an in vitro experiment, FEZF1 can promote the proliferation, migration, and invasion of glioma cells and inhibit cell apoptosis by activating Akt-ERK pathway. All these findings suggest that FEZF1 acts as a key oncogene and predicts a poor prognosis in glioma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.