ArticleJournal of assisted reproduction and genetics2018
Euploid embryos selected by an automated time-lapse system have superior SET outcomes than selected solely by conventional morphology assessment.
Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The Clinical Efficacy of Personalized Embryo Transfer Guided by the Endometrial Receptivity Array/Analysis on IVF/ICSI Outcomes: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2022Pooled it
- Advanced strategies for single embryo selection in assisted human reproduction: A review of clinical practice and research methods.Clinical and experimental reproductive medicine · 2025Article
- Artificial Intelligence, Clinical Decision Support Algorithms, Mathematical Models, Calculators Applications in Infertility: Systematic Review and Hands-On Digital Applications.Mayo Clinic proceedings. Digital health · 2024Review
- Towards Automation in IVF: Pre-Clinical Validation of a Deep Learning-Based Embryo Grading System during PGT-A Cycles.Journal of clinical medicine · 2023Article
- Non-invasive evaluation of embryo quality for the selection of transferable embryos in human in vitro fertilization-embryo transfer.Clinical and experimental reproductive medicine · 2022Article
- Change in the Strategy of Embryo Selection with Time-Lapse System Implementation-Impact on Clinical Pregnancy Rates.Journal of clinical medicine · 2021Article
- The precise determination of the window of implantation significantly improves ART outcomes.Scientific reports · 2021Article
- Good practice recommendations for the use of time-lapse technologyHuman reproduction open · 2020Article
- Lack of evidence to support the superiority of TLI over conventional morphology to select among euploid embryos determined by PGT-A.Journal of assisted reproduction and genetics · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe investigated if automated TLI selection may be a valuable strategy to identify those euploid embryos with the best chances of success.
methodsThis is a unicentric and retrospective study involving 244 patients undergoing preimplantational genetic screening (PGS) cycles with autologous oocytes or oocyte donation (OD) with single euploid embryo transferred. We examined euploid embryos selected for transfer based on morphology evaluation alone (PGS-only; control group) or by assessment using an automated TLI system (Eeva™; PGS-TLI group).
resultsIn both, autologous oocytes and OD patients, significantly better implantation and clinical and ongoing pregnancy rates were obtained in the PGS-TLI group when euploid embryos with high implantation potential as predicted by the automated TLI System (Eeva™) were transferred compared with the PGS-only group. This improvement was also observed when only transfers of good morphological quality embryos were compared. TLI categories showed significant differences on blastocyst formation and euploidy rate.
conclusionsAutomated TLI combined with PGS is a useful prognostic tool to identify euploid embryos with the highest potential for implantation and pregnancy. Further, these results provide evidence that a healthy pregnancy does not only depend upon normal chromosomal status.
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