Evidence map›Paper›PMID 30030699›Full record

ArticleInternal and emergency medicine2018

Hazelnut and cocoa spread improves flow-mediated dilatation in smokers.

Lorenzo Loffredo, Ludovica Perri, Simona Battaglia, Cristina Nocella, Danilo Menichelli, Vittoria Cammisotto, Marta Novo, Roberto Carnevale, Francesco Violi

Abstract read
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In one paragraph

Article in Internal and emergency medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lorenzo LoffredoDepartment of Internal Medicine and Medical Specialties, I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Ludovica PerriDepartment of Internal Medicine and Medical Specialties, I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Simona BattagliaDepartment of Internal Medicine and Medical Specialties, I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Cristina NocellaDepartment of AngioCardioNeurology, IRCCS NeuroMed, 86077, Pozzilli, IS, Italy.
Danilo MenichelliDepartment of Internal Medicine and Medical Specialties, I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Vittoria CammisottoDepartment of Internal Medicine and Medical Specialties, I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Marta NovoDepartment of Internal Medicine and Medical Specialties, I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Roberto CarnevaleDepartment of Internal Medicine and Medical Specialties, I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Francesco VioliDepartment of Internal Medicine and Medical Specialties, I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. francesco.violi@uniroma1.it.
Policlinico Umberto I · ITSapienza University of Rome · ITIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hazelnut and cocoa spread is an Italian product containing cocoa and hazelnut. Several epidemiological studies suggest that cocoa and hazelnuts cocoa exert beneficial cardiovascular effects. To investigate whether in smokers, hazelnut and cocoa spread elicits artery dilatation via down-regulation of oxidative stress. Flow-mediated dilatation (FMD), oxidative stress (as assessed by serum isoprostanes excretion, Nox2 activation and NO bioavailability) and antioxidant status [as assessed by vitamin E levels, plasma total polyphenols and H

Indexed as

ChocolateCorylusAdultAnalysis of VarianceArteriesBiological AvailabilityDilatationFemaleHumansIsoprostanesItalyMaleNADPH Oxidase 2Nitrous OxideOxidative StressPolyphenolsCYBB protein, humanIsoprostanesNADPH Oxidase 2Nitrous OxidePolyphenolsVitamin ECocoaFlow-mediated dilationHazelnutOxidative stress

Identifiers

PMID30030699
OpenAlexW2884445036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.