Evidence map›Paper›PMID 30030665›Full record

ArticleEJNMMI research2018

Reproducible quantification of cardiac sympathetic innervation using graphical modeling of carbon-11-meta-hydroxyephedrine kinetics with dynamic PET-CT imaging.

Tong Wang, Kai Yi Wu, Robert C Miner, Jennifer M Renaud, Rob S B Beanlands, Robert A deKemp

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. F-18 meta-fluorobenzylguanidine PET imaging of myocardial sympathetic innervation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  3. Does quantification of [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  4. Reproducible Quantification of Regional Sympathetic Denervation with [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  5. [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  6. Reliable quantification of myocardial sympathetic innervation and regional denervation using [European journal of nuclear medicine and molecular imaging · 2020
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tong WangNational Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada.
Kai Yi WuNational Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada.
Robert C MinerNational Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada.
Jennifer M RenaudNational Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada.
Rob S B BeanlandsNational Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada.
Robert A deKempNational Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada. radekemp@ottawaheart.ca.ORCID http://orcid.org/0000-0001-9136-5563
University of Ottawa · CA

Funding

Networks of Centres of Excellence of Canada NCE-15-P06-001Ontario Research Foundation ORF-RE07-021
6 · The paper itself

Abstract

backgroundGraphical methods of radiotracer kinetic modeling in PET are ideal for parametric imaging and data quality assurance but can suffer from noise bias. This study compared the Logan and Multilinear Analysis-1 (MA1) graphical models to the standard one-tissue-compartment (1TC) model, including correction for partial-volume effects, in dynamic PET-CT studies of myocardial sympathetic innervation in the left ventricle (LV) using [

methodsTest and retest [

resultsA modeling start-time of t* = 5 min gave the best fit for both Logan and MA1 (R

conclusionsLogan and MA1 models exhibited similar agreement and variability compared to the 1TC for modeling of [

Indexed as

HEDLoganMA1One tissue compartmentSympathetic nervous system

Identifiers

PMID30030665
PMCPMC6054601
OpenAlexW2884210070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.