ArticleIntensive care medicine2018
Early enteral nutrition for cardiogenic or obstructive shock requiring venoarterial extracorporeal membrane oxygenation: a nationwide inpatient database study.
Article in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 83 citations in OpenAlex.
- Impact of the route of nutrition on gut mucosa in ventilated adults with shock: an ancillary of the NUTRIREA-2 trial.Intensive care medicine · 2019Trial
- Erythromycin versus metoclopramide for post-pyloric spiral nasoenteric tube placement: a randomized non-inferiority trial.Intensive care medicine · 2018Trial
- Personalised energy targeting during venovenous ECMO: serial assessment of resting energy expenditure reveals phase-dependent metabolic demand and systematic discordance with predictive equations.Critical care (London, England) · 2026Article
- Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association.Circulation · 2026Review
- Implementation of an Enteral Nutrition Protocol in the Cardiac Care Unit - A Retrospective Study of Critically Ill Cardiovascular Patients.Circulation reports · 2026Article
- A Contemporary Guide of Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock.Journal of cardiovascular development and disease · 2025Review
- Review
- The Japanese Critical Care Nutrition Guideline 2024.Journal of intensive care · 2025Review
- Evidence Summary of Early Enteral Nutrition Support for Adult Patients with Extracorporeal Membrane Oxygenation (ECMO).Journal of multidisciplinary healthcare · 2025Review
- Early Enteral Nutrition May Improve Survival in Patients With Cardiogenic Shock.Emergency medicine international · 2025Article
- Disentangling the phenotypic patterns of hypertension and chronic hypotension.Journal of biomedical informatics · 2024Article
- Article
- Causal inference using observational intensive care unit data: a scoping review and recommendations for future practice.NPJ digital medicine · 2023Article
- Daily Nutritional Intake of Pediatric Patients (N = 64) on Extracorporeal Membrane Oxygenation from 2018 to 2022: A Single-Center Report.Nutrients · 2023Article
- Prevention and management of critical care complications in cardiogenic shock: a narrative review.Journal of intensive care · 2023Review
- Inadequate Energy Delivery Is Frequent among COVID-19 Patients Requiring ECMO Support and Associated with Increased ICU Mortality.Nutrients · 2023Article
- Developing a competency framework for extracorporeal membrane oxygenation nurses: A qualitative study.Nursing open · 2023Article
- Impact of Intensive Care Unit Nutrition on the Microbiome and Patient Outcomes.Anesthesiology clinics · 2023Review
- COVID, the Gut, and Nutritional Implications.Current surgery reports · 2023Review
- Multifactorial Shock: A Neglected Situation in Polytrauma Patients.Journal of clinical medicine · 2022Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeDespite extensive research on enteral nutrition (EN) for patients in shock, it remains unclear whether this should be postponed in patients with cardiogenic or obstructive shock requiring venoarterial extracorporeal membrane oxygenation (VA-ECMO). In this study, we aimed to compare outcomes of early and delayed EN for patients with cardiogenic or obstructive shock requiring VA-ECMO.
methodsIn this retrospective database study drawing on the Japanese Diagnosis Procedure Combination inpatient database from July 2010 to March 2016, we identified patients with cardiogenic or obstructive shock who had received VA-ECMO for more than 2 days. We allocated the patients to two groups: those who received EN within 2 days (early) or 3 days or more (delayed) after starting VA-ECMO. We then used a marginal structural model to analyze associations between early EN and various outcomes, including in-hospital mortality and 28-day mortality.
resultsWe identified 1769 eligible patients during the 69-month study period, 220 of whom (12%) received early EN. After using a marginal structural model to adjust for baseline and time-dependent confounders, we found that the early EN group showed significantly lower in-hospital mortality [hazard ratio 0.78, 95% confidence interval (95% CI) 0.62-0.98, P = 0.032] and lower 28-day mortality (hazard ratio 0.74, 95% CI 0.56-0.97, P = 0.031) than the delayed EN group.
conclusionsAccording to this retrospective database study, early EN is not associated with harm but rather with lower mortality in patients with cardiogenic or obstructive shock requiring at least 2 days of VA-ECMO.
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