ArticleNature chemistry2018
Site-selective photoinduced cleavage and profiling of DNA by chiral semiconductor nanoparticles.
Article in Nature chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 283 citations in OpenAlex.
- Chirality Engineering and Properties in Two-Dimensional Layered Materials.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Nanozymes as Emerging Therapeutics for Asthma: A Redox-Responsive and Immunomodulatory Strategy.Biomedicines · 2026Review
- Spin-driven enantioselective regulation of cyclooxygenase-2 activity for rheumatoid arthritis therapy via chiral gold nanohelices.Nature communications · 2026Article
- Template-free synthesis of colloidal quantum dot assemblies with molecule-like architectures.Nature communications · 2026Article
- Unlocking spontaneous chiral resolution in silver clusters through steric and anionic control.Chemical science · 2026Article
- Recent Advances in Application of Circularly Polarized Luminescence Probes toward Bioimaging Technology.Chemical & biomedical imaging · 2026Review
- Biomolecule-tailored chiral nickel oxide nanozymes amplify autophagy-mediated tumor ablation via synergistic photodynamic-chemodynamic therapy.Materials today. Bio · 2025Article
- Nanozymes expanding the boundaries of biocatalysis.Nature communications · 2025Review
- Inhibition of the cGAS-STING pathwayChemical science · 2025Article
- Stimuli-Responsive Nanomedicines for the Treatment of Non-cancer Related Inflammatory Diseases.ACS nano · 2025Review
- Porous CeOiScience · 2025Article
- Prime Editing: A Revolutionary Technology for Precise Treatment of Genetic Disorders.Cell proliferation · 2025Review
- Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities.Nature communications · 2024Article
- Unraveling the Growth Mechanism of Chiral Inorganic Nanocrystals via High-Resolution Electron Microscopy.Journal of the American Chemical Society · 2024Article
- Inducing Efficient and Multiwavelength Circularly Polarized Emission From Perovskite Nanocrystals Using Chiral Metasurfaces.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Article
- Research progress of chilled meat freshness detection based on nanozyme sensing systems.Food chemistry: X · 2024Review
- Antimicrobial and Antiviral Nanofibers Halt Co-Infection Spread via Nuclease-Mimicry and Photocatalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Biomimetic Chiral Nanomaterials with Selective Catalysis Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Emerging trends in chiral inorganic nanomaterials for enantioselective catalysis.Nature communications · 2024Review
Corrections and comments
- Commented on by
Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene editing is an important genetic engineering technique that enables gene manipulation at the molecular level. It mainly relies on engineered nucleases of biological origin, whose precise functions cannot be replicated in any currently known abiotic artificial material. Here, we show that chiral cysteine-modified CdTe nanoparticles can specifically recognize and, following photonic excitation, cut at the restriction site GAT'ATC (' indicates the cut site) in double-stranded DNA exceeding 90 base pairs, mimicking a restriction endonuclease. Although photoinduced reactive oxygen species are found to be responsible for the cleavage activity, the sequence selectivity arises from the affinity between cysteine and the conformation of the specific DNA sequence, as confirmed by quantum-chemical calculations. In addition, we demonstrate non-enzymatic sequence-specific DNA incision in living cells and in vivo using these CdTe nanoparticles, which may help in the design of abiotic materials for gene editing and other biological applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.