ArticleScientific reports2018
Orbital Frontal Cortex Projections to Secondary Motor Cortex Mediate Exploitation of Learned Rules.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Characteristics of striatal changes in diabetic retinopathy and type 2 diabetes: a resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2026Article
- Whole-brain Mapping of Inputs and Outputs of Specific Orbitofrontal Cortical Neurons in Mice.Neuroscience bulletin · 2024Article
- Performance errors during rodent learning reflect a dynamic choice strategy.Current biology : CB · 2024Article
- The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior.Neuroscience bulletin · 2023Article
- Chronic alcohol exposure alters action control via hyperactive premotor corticostriatal activity.Cell reports · 2023Article
- Orbitofrontal cortex populations are differentially recruited to support actions.Current biology : CB · 2022Article
- Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment.Nature communications · 2022Article
- Call for a more balanced approach to understanding orbital frontal cortex function.Behavioral neuroscience · 2021Article
- Sequential reversal learning: a new touchscreen schedule for assessing cognitive flexibility in mice.Psychopharmacology · 2021Article
- High-frequency neuromodulation improves obsessive-compulsive behavior.Nature medicine · 2021Article
- Secondary motor cortex: Broadcasting and biasing animal's decisions through long-range circuits.International review of neurobiology · 2021Review
- Behavioral Flexibility in Alcohol-Drinking Monkeys: The Morning After.Alcoholism, clinical and experimental research · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Animals face the dilemma between exploiting known opportunities and exploring new ones, a decision-making process supported by cortical circuits. While different types of learning may bias exploration, the circumstances and the degree to which bias occurs is unclear. We used an instrumental lever press task in mice to examine whether learned rules generalize to exploratory situations and the cortical circuits involved. We first trained mice to press one lever for food and subsequently assessed how that learning influenced pressing of a second novel lever. Using outcome devaluation procedures we found that novel lever exploration was not dependent on the food value associated with the trained lever. Further, changes in the temporal uncertainty of when a lever press would produce food did not affect exploration. Instead, accrued experience with the instrumental contingency was strongly predictive of test lever pressing with a positive correlation between experience and trained lever exploitation, but not novel lever exploration. Chemogenetic attenuation of orbital frontal cortex (OFC) projection into secondary motor cortex (M2) biased novel lever exploration, suggesting that experience increases OFC-M2 dependent exploitation of learned associations but leaves exploration constant. Our data suggests exploitation and exploration are parallel decision-making systems that do not necessarily compete.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.