ArticleScientific reports2018
Human coelomic fluid investigation: A MS-based analytical approach to prenatal screening.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Celocentesis: Current Evidence and Future Directions.Journal of clinical medicine · 2026Review
- Identification of novel nutrient sensitive human yolk sac functions required for embryogenesis.Scientific reports · 2024Article
- Article
- Mass Spectrometry-Based Peptide Profiling of Haemolymph fromMolecules (Basel, Switzerland) · 2022Article
- Celomic Fluid: Laboratory Workflow for Prenatal Diagnosis of Monogenic Diseases.Molecular diagnosis & therapy · 2022Article
- Speciation Study on O-Phosphorylethanolamine and O-Phosphorylcholine: Acid-Base Behavior and MgFrontiers in chemistry · 2022Article
- CaFrontiers in chemistry · 2021Article
- Protein Extraction, Enrichment and MALDI MS and MS/MS Analysis from Bitter Orange Leaves (Molecules (Basel, Switzerland) · 2020Article
- 2,3-Diaminopropanols Obtained from d-Serine as Intermediates in the Synthesis of Protected 2,3-l-Diaminopropanoic Acid (l-Dap) Methyl Esters.Molecules (Basel, Switzerland) · 2020Article
- Cloning, Purification, and Characterization of the Catalytic C-Terminal Domain of the Human 3-Hydroxy-3-methyl glutaryl-CoA Reductase: An Effective, Fast, and Easy Method for Testing Hypocholesterolemic Compounds.Molecular biotechnology · 2020Article
- MS-based proteomic analysis of cardiac response to hypoxia in the goldfish (Carassius auratus).Scientific reports · 2019Article
- Molecular species fingerprinting and quantitative analysis of saffron (RSC advances · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coelomic fluid (CF) is the earliest dynamic and complex fluid of the gestational sac. CF contains maternal cells and proteins produced by embryonic cells, tissues and excretions. The biochemical composition of CF is modified throughout the first trimester of pregnancy and its protein profile reflects both physiological/pathological changes affecting the embryo and mother. Identification of variations in the balance of proteins might indicate particular types of pathologies, or ascertain specific genetic disorders. A platform utilizing protein enrichment procedures coupled with shotgun identification and iTRAQ differentiation provided the identification and quantitation of 88 unique embryonic proteins. It is relevant to note that chromosome X protein CXorf23 was found suggesting the embryo sex. Foetal sex was determined by Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) on coelomic cells, foetal tissues and maternal white blood cells, with a 100% concordance rate between iTRAQ-MS/MS and QF-PCR data. The functional associations among the identified proteins were investigated using STRING database. Open Targets Platform showed as significant the following therapeutic areas: nervous, respiratory, eye and head system disease.
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