ArticleScientific reports2018
Coactivation of MEP-biosynthetic genes and accumulation of abietane diterpenes in Salvia sclarea by heterologous expression of WRKY and MYC2 transcription factors.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 53 citations in OpenAlex.
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- Genome-wide characterization and expression analysis of WRKY family genes in the biosynthesis of triptolide in Tripterygium wilfordii.BMC genomics · 2025Article
- The Role of MYC2 Transcription Factors in Plant Secondary Metabolism and Stress Response Mechanisms.Plants (Basel, Switzerland) · 2025Review
- Plant Secondary Metabolites-Central Regulators Against Abiotic and Biotic Stresses.Metabolites · 2025Review
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- Identification of two terpenoids that accumulate in Chinese water chestnut in response to fresh-cut processing.Food science & nutrition · 2023Article
- TcbHLH14 a Jasmonate Associated MYC2-like Transcription Factor Positively Regulates Pyrethrin Biosynthesis inInternational journal of molecular sciences · 2023Article
- 3-Hydroxy-3-methylglutaryl coenzyme A reductase genes from Glycine max regulate plant growth and isoprenoid biosynthesis.Scientific reports · 2023Article
- Regulation of the regulators: Transcription factors controlling biosynthesis of plant secondary metabolites during biotic stresses and their regulation by miRNAs.Frontiers in plant science · 2023Review
- Plant hairy roots for the production of extracellular vesicles with antitumor bioactivity.Communications biology · 2022Article
- Genome-wide analysis of WRKY transcription factor genes inFrontiers in plant science · 2022Article
- In-depth analysis of large-scale screening of WRKY members based on genome-wide identification.Frontiers in genetics · 2022Article
- Molecular cloning and expression analysis of a WRKY transcription factor gene,Plant signaling & behavior · 2021Article
- Identification of the Group IIIPlants (Basel, Switzerland) · 2021Article
- Transcriptome Analysis of Light-Regulated Monoterpenes Biosynthesis in Leaves ofPlants (Basel, Switzerland) · 2021Article
- Plant-Derived Nano and Microvesicles for Human Health and Therapeutic Potential in Nanomedicine.Pharmaceutics · 2021Review
- Transcriptome analysis of twoPeerJ · 2021Article
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6 authors at 1 institution in 1 country.
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Abstract
Plant abietane diterpenoids (e.g. aethiopinone, 1- oxoaethiopinone, salvipisone and ferruginol), synthesized in the roots of several Salvia spp, have antibacterial, antifungal, sedative and anti-proliferative properties. Recently we have reported that content of these compounds in S. sclarea hairy roots is strongly depending on transcriptional regulation of genes belonging to the plastidial MEP-dependent terpenoid pathway, from which they mostly derive. To boost the synthesis of this interesting class of compounds, heterologous AtWRKY18, AtWRKY40, and AtMYC2 TFs were overexpressed in S. sclarea hairy roots and proved to regulate in a coordinated manner the expression of several genes encoding enzymes of the MEP-dependent pathway, especially DXS, DXR, GGPPS and CPPS. The content of total abietane diterpenes was enhanced in all overexpressing lines, although in a variable manner due to a negative pleiotropic effect on HR growth. Interestingly, in the best performing HR lines overexpressing the AtWRKY40 TF induced a significant 4-fold increase in the final yield of aethiopinone, for which we have reported an interesting anti-proliferative activity against resistant melanoma cells. The present results are also informative and instrumental to enhance the synthesis of abietane diterpenes derived from the plastidial MEP-derived terpenoid pathway in other Salvia species.
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