Evidence map›Paper›PMID 30030465›Full record

ArticleScientific reports2018

Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.

Esther Paulo, Dongmei Wu, Yangmeng Wang, Yun Zhang, Yixuan Wu, Danielle L Swaney, Margaret Soucheray, David Jimenez-Morales, Ajay Chawla, Nevan J Krogan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Esther PauloCardiovascular Research Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Dongmei WuCardiovascular Research Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Yangmeng WangCardiovascular Research Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Yun ZhangCardiovascular Research Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Yixuan WuCardiovascular Research Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Danielle L SwaneyDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Margaret SoucherayDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.
David Jimenez-MoralesDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0003-4356-6461
Ajay ChawlaCardiovascular Research Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Nevan J KroganDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.
Biao WangCardiovascular Research Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA, 94158, USA. biao.wang@ucsf.edu.ORCID 0000-0001-8514-3825
University of California, San Francisco · USQB3 · US

Funding

X-ray Screening and Rapid Structure DeterminationP50GM082250 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KROGAN, NEVAN J · 2007 to 2018
$48.8M
KOMP2-Phase3 Production and Phenotyping by the DTCC Consortium TCP Transfer to UC DavisUM1OD023221 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2016 to 2026
$45.7M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Project 3: Autophagy dysfunction and neuronal activity in FTDU54NS100717 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GAN, LI · 2016 to 2020
$10.8M
Innate Immune Mechanisms of ThermogenesisR01DK094641 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, BIAO · 2011 to 2019
$3.5M
Transcriptional control in brown and beige adipocytesR01DK105175 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, BIAO · 2015 to 2019
$1.8M
Myeloid Cell Functions in Obesity and Diabetes.R01DK101064 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAWLA, AJAY · 2015 to 2018
$1.6M
NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK094641NIDDK NIH HHS R01 DK101064NIDDK NIH HHS R01 DK105175NIGMS NIH HHS P50 GM082250NIH HHS UM1 OD023221NINDS NIH HHS U54 NS100717
6 · The paper itself

Abstract

Various physiological stimuli, such as cold environment, diet, and hormones, trigger brown adipose tissue (BAT) to produce heat through sympathetic nervous system (SNS)- and β-adrenergic receptors (βARs). The βAR stimulation increases intracellular cAMP levels through heterotrimeric G proteins and adenylate cyclases, but the processes by which cAMP modulates brown adipocyte function are not fully understood. Here we described that specific ablation of cAMP production in brown adipocytes led to reduced lipolysis, mitochondrial biogenesis, uncoupling protein 1 (Ucp1) expression, and consequently defective adaptive thermogenesis. Elevated cAMP signaling by sympathetic activation inhibited Salt-inducible kinase 2 (Sik2) through protein kinase A (PKA)-mediated phosphorylation in brown adipose tissue. Inhibition of SIKs enhanced Ucp1 expression in differentiated brown adipocytes and Sik2 knockout mice exhibited enhanced adaptive thermogenesis at thermoneutrality in an Ucp1-dependent manner. Taken together, our data indicate that suppressing Sik2 by PKA-mediated phosphorylation is a requisite for SNS-induced Ucp1 expression and adaptive thermogenesis in BAT, and targeting Sik2 may present a novel therapeutic strategy to ramp up BAT thermogenic activity in humans.

Indexed as

Adipose Tissue, BrownAnimalsCyclic AMPCyclic AMP-Dependent Protein KinasesHumansMicePhosphorylationProtein Serine-Threonine KinasesReceptors, Adrenergic, betaSympathetic Nervous SystemThermogenesisUncoupling Protein 1Cyclic AMPCyclic AMP-Dependent Protein KinasesProtein Serine-Threonine KinasesReceptors, Adrenergic, betasalt-inducible kinase-2, humanUncoupling Protein 1

Identifiers

PMID30030465
PMCPMC6054673
OpenAlexW2884188461

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.