ArticleScientific reports2018
Cellular-resolution 3D virtual histology of human coronary arteries using x-ray phase tomography.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- X-ray histology on rapidly fixed fresh tumor tissue samples for fast resection margin assessment.Scientific reports · 2026Article
- Three-dimensional high-content imaging of unstained soft tissue with subcellular resolution using a laboratory-based X-ray microscope.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- AI-based modality-agnostic classification system for vascular calcifications.Scientific reports · 2025Article
- 3D histology of human heart-forming organoids by X-ray phase-contrast tomography.Communications biology · 2025Article
- Synchrotron-based X-ray 3D phase contrast imaging and analysis of transmural myocardial tissue from heart failure patients.Scientific reports · 2025Article
- 3D imaging of SARS-CoV-2 infected hamster lungs by X-ray phase contrast tomography enables drug testing.Scientific reports · 2024Article
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- X-ray phase contrast reveals soft tissue and shell growth lines in mollusks.Communications biology · 2024Article
- Acquisition of a single grid-based phase-contrast X-ray image using instantaneous frequency and noise filtering.Biomedical engineering online · 2022Article
- Impact of intraventricular septal fiber orientation on cardiac electromechanical function.American journal of physiology. Heart and circulatory physiology · 2022Article
- Can laboratory x-ray virtual histology provide intraoperative 3D tumor resection margin assessment?Journal of medical imaging (Bellingham, Wash.) · 2022Article
- Sub-micrometer morphology of human atherosclerotic plaque revealed by synchrotron radiation-based μCT-A comparison with histology.PloS one · 2022Article
- Article
- Edge-illumination x-ray phase-contrast imaging.Journal of physics. Condensed matter : an Institute of Physics journal · 2021Review
- Multiscale photonic imaging of the native and implanted cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Advances in CT Techniques in Vascular Calcification.Frontiers in cardiovascular medicine · 2021Review
- Next-Generation Hardware Advances in CT: Cardiac Applications.Radiology · 2021Review
- Automated Machine-Learning Framework Integrating Histopathological and Radiological Information for Predicting IDH1 Mutation Status in Glioma.Frontiers in bioinformatics · 2021Article
- Deep learning reveals 3D atherosclerotic plaque distribution and composition.Scientific reports · 2020Article
- 3D virtual histology of human pancreatic tissue by multiscale phase-contrast X-ray tomography.Journal of synchrotron radiation · 2020Article
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4 authors.
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Abstract
High-spatial-resolution histology of coronary artery autopsy samples play an important role for understanding heart disease such as myocardial infarction. Unfortunately, classical histology is often destructive, has thick slicing, requires extensive sample preparation, and is time-consuming. X-ray micro-CT provides fast nondestructive 3D imaging but absorption contrast is often insufficient, especially for observing soft-tissue features with high resolution. Here we show that propagation-based x-ray phase-contrast tomography has the resolution and contrast to image clinically relevant soft-tissue features in intact coronary artery autopsy samples with cellular resolution. We observe microscopic lipid-rich plaques, individual adipose cells, ensembles of few foam cells, and the thin fibrous cap. The method relies on a small-spot laboratory x-ray microfocus source, and provides high-spatial resolution in all three dimensions, fast data acquisition, minimum sample distortion and requires no sample preparation.
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