ArticleScientific reports2018
Experimentally induced metamorphosis in highly regenerative axolotl (ambystoma mexicanum) under constant diet restructures microbiota.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Polyphenism Through RNA Chemical Modifications.Molecular ecology · 2026Review
- Exploring the role of ergothioneine and mycorrhizal fungi in shaping the wheat soil microbiome.Environmental microbiome · 2026Article
- Ultrastructural and histochemical insights into neotenic and metamorphic axolotl lungs with clues to pulmonary regeneration.Scientific reports · 2026Article
- Pooled feces reduce the inter-sample variation of microbiota in pig models.BMC microbiology · 2026Article
- A spatial transcriptomics comparison of the adult versus metamorphosed axolotl brain.Scientific data · 2026Article
- Identification of Opportunistic Pathogens on the Skin of Salamanders for Use as Molecular Targets of a De Novo Design of Multitarget Anti-International journal of microbiology · 2026Article
- Research Status and Prospect of Amphibian Symbiotic Microbiota.Animals : an open access journal from MDPI · 2025Review
- Investigating Neotenic and Metamorphic Axolotl Brain Complexity: A Stereological and Immunohistochemical Perspective.The Journal of comparative neurology · 2025Article
- Ultrasound description of the coelomic cavity of the axolotl (Ambystoma mexicanum) in a clinically healthy population: a pilot study.Scientific reports · 2024Article
- Screening Salamanders for Symbionts.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The skin microbiota of the axolotl Ambystoma altamirani is highly influenced by metamorphosis and seasonality but not by pathogen infection.Animal microbiome · 2022Article
- Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution.Nature communications · 2022Article
- The amazing and anomalous axolotls as scientific models.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Altered metabolic state impedes limb regeneration in salamanders.Zoological research · 2021Article
- Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages.Data in brief · 2020Article
- Advancements to the Axolotl Model for Regeneration and Aging.Gerontology · 2020Review
- Integrative Analysis of Axolotl Gene Expression Data from Regenerative and Wound Healing Limb Tissues.Scientific reports · 2019Article
- Longitudinal 16S rRNA data derived from limb regenerative tissue samples of axolotl Ambystoma mexicanum.Scientific data · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axolotl (Ambystoma mexicanum) is a critically endangered salamander species and a model organism for regenerative and developmental biology. Despite life-long neoteny in nature and in captive-bred colonies, metamorphosis of these animals can be experimentally induced by administering Thyroid hormones (THs). However, microbiological consequences of this experimental procedure, such as host microbiota response, remain largely unknown. Here, we systematically compared host bacterial microbiota associated with skin, stomach, gut tissues and fecal samples, between neotenic and metamorphic axolotls based on 16S rRNA gene sequences. Our results show that distinct bacterial communities inhabit individual organs of axolotl and undergo substantial restructuring through metamorphosis. Skin microbiota among others, shifted sharply, as highlighted by a major transition from Firmicutes-enriched to Proteobacteria-enriched relative abundance and precipitously decreased diversity. Fecal microbiota of neotenic and metamorphic axolotl shared relatively higher similarity, suggesting that diet continues to shape microbiota despite fundamental transformations in the host digestive organs. We also reproduced the previous finding on reduction in regenerative capacity in limbs of axolotl following metamorphosis, highlighting the need to investigate whether shifts in microbiota is causally linked to regenerative capacity of axolotl. The initial results on axolotl microbiota provide novel insights into microbiological aspects of axolotl metamorphosis and will establish a baseline for future in-depth studies.
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