ArticleScientific reports2018
Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion.Cell biomaterials · 2026Article
- Label-free tracking of subcortical white matter degradationBiomedical optics express · 2026Article
- Intestinal aging-related immune dysfunction: mechanisms and interventions.Acta biochimica et biophysica Sinica · 2026Review
- Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion.bioRxiv : the preprint server for biology · 2025Article
- Intestinal obstruction caused by early stage primary ileum adenocarcinoma: A case report and review of literature.World journal of gastrointestinal oncology · 2025Article
- Imaging the enteric nervous system.Frontiers in neuroanatomy · 2025Review
- The emerging role of intestinal stem cells in ulcerative colitis.Frontiers in medicine · 2025Review
- Review
- The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review.Aging cell · 2024Review
- Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges.Experimental & molecular medicine · 2024Review
- Article
- Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis.Molecular cancer research : MCR · 2023Article
- Intestinal stem cell aging at single-cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics.Aging cell · 2023Article
- Intravital imaging of immune responses in intestinal inflammation.Inflammation and regeneration · 2023Review
- Article
- Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids.Cell stem cell · 2021Article
- Signaling Network Centered on mTORC1 Dominates Mammalian Intestinal Stem Cell Ageing.Stem cell reviews and reports · 2021Review
- Age-related changes in intestinal immunity and the microbiome.Journal of leukocyte biology · 2021Review
- Aging-Related Impairments to M Cells in Peyer's Patches Coincide With Disturbances to Paneth Cells.Frontiers in immunology · 2021Article
- Capturing Stem Cell Behavior Using Intravital and Live Cell Microscopy.Cold Spring Harbor perspectives in biology · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Despite the continuous renewal and turnover of the small intestinal epithelium, the intestinal crypt maintains a 'soccer ball-like', alternating pattern of stem and Paneth cells at the base of the crypt. To study the robustness of the alternating pattern, we used intravital two-photon microscopy in mice with fluorescently-labeled Lgr5+ intestinal stem cells and precisely perturbed the mosaic pattern with femtosecond laser ablation. Ablation of one to three cells initiated rapid motion of crypt cells that restored the alternation in the pattern within about two hours with only the rearrangement of pre-existing cells, without any cell division. Crypt cells then performed a coordinated dilation of the crypt lumen, which resulted in peristalsis-like motion that forced damaged cells out of the crypt. Crypt cell motion was reduced with inhibition of the ROCK pathway and attenuated with old age, and both resulted in incomplete pattern recovery. This suggests that in addition to proliferation and self-renewal, motility of stem cells is critical for maintaining homeostasis. Reduction of this newly-identified behavior of stem cells could contribute to disease and age-related changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.