ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Age-Related Trajectories of Functional Coupling between the VTA and Nucleus Accumbens Depend on Motivational State.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 35 citations in OpenAlex.
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- Striatal and hippocampal contributions to value-based learning in adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
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- Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.Cell reports · 2025Article
- Adolescent maturation of dorsolateral prefrontal cortex glutamate:GABA and cognitive function is supported by dopamine-related neurobiology.Molecular psychiatry · 2025Article
- Understanding the development of a functional brain circuit: reward processing as an illustration.Translational psychiatry · 2025Review
- Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood.Developmental cognitive neuroscience · 2024Article
- Adolescent-to-adult gains in cognitive flexibility are adaptively supported by reward sensitivity, exploration, and neural variability.Current opinion in behavioral sciences · 2024Article
- Adolescent neurocognitive development and decision-making abilities regarding gender-affirming care.Developmental cognitive neuroscience · 2024Review
- Genetic variation in endocannabinoid signaling: Anxiety, depression, and threat- and reward-related brain functioning during the transition into adolescence.Behavioural brain research · 2024Article
- Awake Hippocampal-Cortical Co-reactivation Is Associated with Forgetting.Journal of cognitive neuroscience · 2023Article
- Pathways to Psychopathology Among Autistic Adults.Current psychiatry reports · 2023Review
- Context-specific abnormalities of the central executive network in first-episode psychosis: relationship with cognition.Psychological medicine · 2022Article
- Contributions of dopamine-related basal ganglia neurophysiology to the developmental effects of incentives on inhibitory control.Developmental cognitive neuroscience · 2022Article
- Is Adolescence a Sensitive Period for the Development of Incentive-Reward Motivation?Current topics in behavioral neurosciences · 2022Review
- Dopamine-related striatal neurophysiology is associated with specialization of frontostriatal reward circuitry through adolescence.Progress in neurobiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Over-engagement of the mesolimbic dopamine system is thought to enhance motivation in adolescents. Whereas human neuroimaging has characterized event-evoked responses of the mesolimbic system in adolescents, research has yet to characterize state-dependent engagement (i.e., seconds to minutes) of this system in goal-relevant contexts. In the current longitudinal study, we characterized age-related changes in state-dependent coupling in male and female human participants ranging in age from adolescence to adulthood. Analyses focused on two key regions of the mesolimbic dopamine system, the ventral tegmental area (VTA) and nucleus accumbens (NAcc). Although there were no differences in VTA-NAcc functional coupling in a resting-state context, VTA-NAcc functional coupling was enhanced in preadolescence/early adolescence and decreased into adulthood in a motivational context, in which individuals had to translate goal-relevant cues into instrumental actions. Furthermore, we found that task-related activation in orbitofrontal cortex, middle temporal gyrus, and visual association cortex partially mediated age-related changes in state-dependent VTA-NAcc functional coupling. These results extend prior models of neurodevelopment by showing a relationship between cortical event-evoked activation and state-dependent increases in subcortical engagement of mesolimbic systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.