Evidence map›Paper›PMID 30030371›Full record

ArticleJournal of cell science2018

Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane.

Varsha Singh, Jianbo Yang, Jianyi Yin, Robert Cole, Ming Tse, Diego E Berman, Scott A Small, Gregory Petsko, Mark Donowitz

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Human epiblast lumenogenesis: From a cell aggregate to a lumenal cyst.Seminars in cell & developmental biology · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. The retromer is co-opted to deliver lipid enzymes for the biogenesis of lipid-enriched tombusviral replication organelles.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of human NHE3 regulating its expression and activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  13. The emerging role of sorting nexins in cardiovascular diseases.Clinical science (London, England : 1979) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Varsha SinghDepartments of Medicine and Physiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA mdonowit@jhmi.edu vsingh11@jhmi.edu.ORCID 0000-0003-0796-2619
Jianbo YangDepartments of Medicine and Physiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Jianyi YinDepartments of Medicine and Physiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Robert ColeDepartment of Biological Chemistry, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Ming TseDepartments of Medicine and Physiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Diego E BermanThe Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Scott A SmallThe Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Gregory PetskoHelen and Robert Appel Alzheimer's Disease Research Institute and Department of Neurology, Weill Cornell Medical College, New York, NY 10021, USA.
Mark DonowitzDepartments of Medicine and Physiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA mdonowit@jhmi.edu vsingh11@jhmi.edu.ORCID 0000-0003-0477-8824
Johns Hopkins University · USMIND Research Institute · USCornell University · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Project 3 - Human colonoids as a model for the pathobiology of EHECP01AI125181 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RUIZ, FERNANDO · 2016 to 2025
$18.6M
Two-Photon Microscopy Imaging CoreP01DK072084 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2006 to 2013
$12.7M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
Translational Approaches to Develop Drug Therapy for DiarrheaR24DK099803 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2014 to 2019
$8.9M
DIARRHEAL DISEASES: A PHYSIOLOGIC APPROACH TO TREATMENTR01DK026523 · NIDDK · TUFTS MEDICAL CENTER · PI DONOWITZ, MARK · 1986 to 2016
$7.8M
PDZ Domain Proteins and NHE3 RegulationR01DK061765 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK, TSE, CHUNG-MING · 2004 to 2013
$4.7M
NCATS NIH HHS UL1 TR000003NIAID NIH HHS P01 AI125181NIDDK NIH HHS P01 DK072084NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK026523NIDDK NIH HHS R01 DK061765NIDDK NIH HHS R24 DK099803
6 · The paper itself

Abstract

Cholera toxin (CT) causes severe diarrhea by increasing intracellular cAMP leading to a PKA-dependent increase in Cl

Indexed as

Caco-2 CellsCell MembraneCells, CulturedCholera ToxinDown-RegulationEndocytosisEndosomesHEK293 CellsHeLa CellsHumansMolecular ChaperonesProtein TransportSorting NexinsVesicular Transport ProteinsCholera ToxinMolecular ChaperonesSNX27 protein, humanSorting NexinsVesicular Transport ProteinsApical traffickingCholera toxinEarly endosomesExocytosisNHE3PDZRetromerSecretory diarrheaSNX27

Identifiers

PMID30030371
PMCPMC6127729
OpenAlexW2883696571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.