Evidence map›Paper›PMID 30030120›Full record

ArticleJournal of biomedical informatics2018

Benchmarking relief-based feature selection methods for bioinformatics data mining.

Ryan J Urbanowicz, Randal S Olson, Peter Schmitt, Melissa Meeker, Jason H Moore

Abstract read
In one paragraph

Article in Journal of biomedical informatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed.

  1. Trial
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  5. Survival-LCS: Rule-Based Survival Analysis without Proportional Hazard Assumptions.ACM transactions on evolutionary learning and optimization · 2026
    Article
  6. Phase-Alternation and Tree-Initialization to Facilitate Interpretable Rule-based Machine Learning.Genetic and Evolutionary Computation Conference : [proceedings]. Genetic and Evolutionary Computation Conference · 2026
    Article
  7. Article
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  15. Rule-based Machine Learning: Separating Rule and Rule-Set Pareto-Optimization for Interpretable Noise-Agnostic Modeling.Genetic and Evolutionary Computation Conference : [proceedings]. Genetic and Evolutionary Computation Conference · 2025
    Article
  16. Article
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  18. Article
  19. Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryan J UrbanowiczInstitute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: ryanurb@upenn.edu.
Randal S OlsonInstitute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: olsonran@upenn.edu.
Peter SchmittInstitute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: pschmitt@upenn.edu.
Melissa MeekerUrsinus College, Collegeville, PA 19426, USA. Electronic address: memeeker@ursinus.edu.
Jason H MooreInstitute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: jhmoore@upenn.edu.

Funding

Human Pancreas Analysis Program for Type 1 Diabetes - HPAP-T1DU01DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MARK A. ATKINSON, KLAUS H KAESTNER · 2021 to 2026
$46.8M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3M
Rare Diseases Data Management and Coordinating CenterU01TR001263 · NCATS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2018
$28.1M
Penn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8M
Bioinformatics Strategies for Genome-Wide Association StudiesR01LM010098 · NLM · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H., WILLIAMS, SCOTT MATTHEW · 2009 to 2023
$5.1M
Machine Learning Prediction of Cancer SusceptibilityR01LM009012 · NLM · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H. · 2006 to 2014
$3.3M
Approaches to Genetic Heterogeneity of Obstructive Sleep ApneaR01HL134015 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I, ROBISHAW, JANET D · 2016 to 2019
$3.2M
Biomedical Computing and Informatics Strategies for Infectious Disease ResearchR01AI116794 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H. · 2016 to 2020
$2.9M
Bioinformatics Strategies for Multidimensional Brain Imaging GeneticsR01LM011360 · NLM · INDIANA UNIVERSITY INDIANAPOLIS · PI MOORE, JASON H., SAYKIN, ANDREW J · 2012 to 2015
$1.4M
Bioinformatics Approaches to Visual Disease GeneticsR01EY022300 · NEI · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H. · 2012 to 2014
$947k
NCATS NIH HHS U01 TR001263NEI NIH HHS R01 EY022300NHLBI NIH HHS R01 HL134015NIAID NIH HHS R01 AI116794NIDDK NIH HHS U01 DK112217NIDDK NIH HHS UC4 DK112217NIEHS NIH HHS P30 ES013508NLM NIH HHS R01 LM009012NLM NIH HHS R01 LM010098NLM NIH HHS R01 LM011360
6 · The paper itself

Abstract

Modern biomedical data mining requires feature selection methods that can (1) be applied to large scale feature spaces (e.g. 'omics' data), (2) function in noisy problems, (3) detect complex patterns of association (e.g. gene-gene interactions), (4) be flexibly adapted to various problem domains and data types (e.g. genetic variants, gene expression, and clinical data) and (5) are computationally tractable. To that end, this work examines a set of filter-style feature selection algorithms inspired by the 'Relief' algorithm, i.e. Relief-Based algorithms (RBAs). We implement and expand these RBAs in an open source framework called ReBATE (Relief-Based Algorithm Training Environment). We apply a comprehensive genetic simulation study comparing existing RBAs, a proposed RBA called MultiSURF, and other established feature selection methods, over a variety of problems. The results of this study (1) support the assertion that RBAs are particularly flexible, efficient, and powerful feature selection methods that differentiate relevant features having univariate, multivariate, epistatic, or heterogeneous associations, (2) confirm the efficacy of expansions for classification vs. regression, discrete vs. continuous features, missing data, multiple classes, or class imbalance, (3) identify previously unknown limitations of specific RBAs, and (4) suggest that while MultiSURF

Indexed as

AlgorithmsBenchmarkingComputational BiologyComputer SimulationDatabases, GeneticData MiningEpistasis, GeneticHumansClassificationEpistasisFeature selectionGenetic heterogeneityRegressionReliefF

Identifiers

PMID30030120
PMCPMC6299838

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.