Evidence map›Paper›PMID 30029866›Full record

ArticleThe Journal of pediatrics2018

Respiratory Health and Lung Function in Children Exposed to the World Trade Center Disaster.

Alice Trye, Kenneth I Berger, Mrudula Naidu, Teresa M Attina, Joseph Gilbert, Tony T Koshy, Xiaoxia Han, Michael Marmor, Yongzhao Shao, Robert Giusti and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02068183 (Early Identification of World Trade Center Conditions in Adolescents), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02068183 completednot on this map

Early Identification of World Trade Center Conditions in Adolescents

TypeobservationalSponsorNYU Langone HealthRan2013 to 2016Enrolled402ConditionsAsthma, Hypertension, Cardiovascular Risk Factor, Insulin Resistance
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Scientific Value of the Sub-Cohort of Children in the World Trade Center Health Registry.International journal of environmental research and public health · 2022
    Article
  3. Article
  4. Article
  5. The Development of a WTC Environmental Health Center Pan-Cancer Database.International journal of environmental research and public health · 2021
    Article
  6. World Trade Center Health Program: First Decade of Research.International journal of environmental research and public health · 2020
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alice TryeDepartment of Pediatrics, New York University School of Medicine, New York, NY.
Kenneth I BergerDepartment of Medicine, New York University School of Medicine, New York, NY.
Mrudula NaiduDepartment of Pediatrics, New York University School of Medicine, New York, NY.
Teresa M AttinaDepartment of Pediatrics, New York University School of Medicine, New York, NY.
Joseph GilbertDepartment of Pediatrics, New York University School of Medicine, New York, NY.
Tony T KoshyDepartment of Pediatrics, New York University School of Medicine, New York, NY.
Xiaoxia HanDepartment of Population Health, New York University School of Medicine, New York, NY.
Michael MarmorDepartment of Population Health, New York University School of Medicine, New York, NY.
Yongzhao ShaoDepartment of Population Health, New York University School of Medicine, New York, NY; Department of Environmental Medicine, New York University School of Medicine, New York, NY.
Robert GiustiDepartment of Pediatrics, New York University School of Medicine, New York, NY.
Roberta M GoldringDepartment of Medicine, New York University School of Medicine, New York, NY.
Leonardo TrasandeDepartment of Pediatrics, New York University School of Medicine, New York, NY; Department of Population Health, New York University School of Medicine, New York, NY; Department of Environmental Medicine, New York University School of Medicine, New York, NY; New York University Wagner School of Public Service, New York, NY; New York University College of Global Public Health, New York, NY. Electronic address: leonardo.trasande@nyumc.org.

Funding

NIOSH CDC HHS U01 OH010394NIOSH CDC HHS U01 OH010714
6 · The paper itself

Abstract

objectivesTo compare lung function in a representative sample of World Trade Center (WTC)-exposed children with matched comparisons, and examine relationships with reported exposures. STUDY

designStudy population consisted of 402 participants. Oscillometry, spirometry, and plethysmography were performed on WTC Health Registry (WTCHR) respondents who were ≤8 years of age on September 11, 2001 (n = 180) and a sociodemographically matched group of New York City residents (n = 222). We compared lung function by study arm (WTCHR and comparison group) as well as dust cloud (acute); home dust (subchronic); and other traumatic, nondust exposures.

resultsIn multivariable models, post-9/11 risk of incident asthma was higher in the WTCHR participants than in the comparison group (OR 1.109, 95% CI 1.021, 1.206; P = .015). Comparing by exposure rather than by group, dust cloud (OR 1.223, 95% CI 1.095, 1.365; P < .001) and home dust (OR 1.123, 95% CI 1.029, 1.226; P = .009) exposures were also associated with a greater risk of incidence of post-9/11 asthma. No differences were identified for lung function measures.

conclusionsAlthough we cannot exclude an alternative explanation to the null findings, these results may provide some measure of reassurance to exposed children and their families regarding long-term consequences. Further study with bronchodilation and/or methacholine challenge may be needed to identify and further evaluate effects of WTC exposure. Biomarker studies may also be more informative in delineating exposure-outcome relationships.

trial registrationClinicalTrials.gov: NCT02068183.

Indexed as

DisastersHealth StatusRegistriesRespiratory Physiological PhenomenaAir PollutantsChildChild, PreschoolDustEnvironmental ExposureFemaleHumansIncidenceInfantInfant, NewbornMaleNew York CityAir PollutantsDustasthmadust cloud (acute) exposurehome dust (subchronic) exposuretraumatic nondust exposures

Identifiers

PMID30029866
PMCPMC8336626

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.