ArticleInfection and immunity1986
Mycobacterium leprae fails to stimulate phagocytic cell superoxide anion generation.
Article in Infection and immunity, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 81 citations in OpenAlex.
- Reactive Chlorine Species Reversibly Inhibit DnaB Protein Splicing in Mycobacteria.Microbiology spectrum · 2021Article
- Article
- The continuing challenges of leprosy.Clinical microbiology reviews · 2006Review
- Opsonized virulent Edwardsiella tarda strains are able to adhere to and survive and replicate within fish phagocytes but fail to stimulate reactive oxygen intermediates.Infection and immunity · 2001Article
- Identification of proteins of Francisella tularensis induced during growth in macrophages and cloning of the gene encoding a prominently induced 23-kilodalton protein.Infection and immunity · 1997Article
- Stimulation or inhibition of the respiratory burst in cultured macrophages in a mycobacterium model: initial stimulation is followed by inhibition after phagocytosis.Infection and immunity · 1994Article
- Acid phosphatase activity in Coxiella burnetii: a possible virulence factor.Infection and immunity · 1993Article
- Antigen-coated latex particles as a model system for probing monocyte responses in leprosy.Infection and immunity · 1993Article
- Bordetella pertussis induces respiratory burst activity in human polymorphonuclear leukocytes.Infection and immunity · 1992Article
- Stimulation of human neutrophil oxidative metabolism by nonopsonized Neisseria gonorrhoeae.Infection and immunity · 1991Article
- Phenolic glycolipid-1 of Mycobacterium leprae binds complement component C3 in serum and mediates phagocytosis by human monocytes.The Journal of experimental medicine · 1991Article
- Effect of tumour promoters on poly ADP-ribosylation in human epidermoid carcinoma HeP2 cells.International journal of experimental pathology · 1990Article
- Phagocytosis of leprosy bacilli is mediated by complement receptors CR1 and CR3 on human monocytes and complement component C3 in serum.The Journal of clinical investigation · 1990Article
- A complex component modulating immune-deficient cells in leprosy patients leading to loss of viability of Mycobacterium leprae--a possible vaccine.Clinical and experimental immunology · 1990Article
- Microbial glycolipids: possible virulence factors that scavenge oxygen radicals.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Effects of Histoplasma capsulatum on murine macrophage functions: inhibition of macrophage priming, oxidative burst, and antifungal activities.Infection and immunity · 1989Article
- Effect of Mycobacterium tuberculosis-derived sulfolipid I on human phagocytic cells.Infection and immunity · 1988Article
- Induction of unresponsiveness to gamma interferon in macrophages infected with Mycobacterium leprae.Infection and immunity · 1988Article
- Cytokine regulation of the intracellular growth of Mycobacterium paratuberculosis in bovine monocytes.Infection and immunity · 1988Article
- A capsule-deficient mutant of Francisella tularensis LVS exhibits enhanced sensitivity to killing by serum but diminished sensitivity to killing by polymorphonuclear leukocytes.Infection and immunity · 1988Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Mycobacterium leprae is an intracellular pathogen that is ingested by and proliferates within cells of the monocyte/macrophage series. Mechanisms by which intracellular pathogens resist destruction may involve failure to elicit a phagocyte "respiratory burst" or resistance to toxic oxygen derivatives and lysosomal enzymes. We have studied the ability of M. leprae and Mycobacterium bovis BCG to stimulate the generation of superoxide anion (O2-) in vitro by human blood neutrophils and monocytes and murine peritoneal macrophages. M. leprae bacteria failed to stimulate significant O2- release except at high bacteria-to-cell ratios (greater than 50:1) whether or not they were pretreated with normal serum or serum from patients with lepromatous leprosy. Either viable or irradiated BCG; on the other hand, stimulated the three cell types to release significant amounts of O2- when challenged with as few as 10 organisms per cell. Serum pretreatment enhanced the release of O2- by the three cell types. Preincubation for 18 h with viable M. leprae did not inhibit the ability of monocytes to respond with an oxidative burst to phagocytic stimuli. The failure of M. leprae to stimulate phagocyte O2- generation may be an important factor in its pathogenicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.