Evidence map›Paper›PMID 30029628›Full record

SynthesisBMC public health2018

Social determinants of prostate cancer in the Caribbean: a systematic review and meta-analysis.

Catherine R Brown, Ian Hambleton, Shawn M Hercules, Nigel Unwin, Madhuvanti M Murphy, E Nigel Harris, Rainford Wilks, Marlene MacLeish, Louis Sullivan, Natasha Sobers-Grannum and 1 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Article
  6. Smoking and the risk of prostate cancer: a review of risk and disease progression.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Review
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  10. Salud publica de Mexico · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Catherine R BrownGeorge Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, The University of the West Indies, Bridgetown, Barbados. catherine.brown@cavehill.uwi.edu.ORCID 0000-0003-4928-1061
Ian HambletonGeorge Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, The University of the West Indies, Bridgetown, Barbados.
Shawn M HerculesGeorge Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, The University of the West Indies, Bridgetown, Barbados.
Nigel UnwinGeorge Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, The University of the West Indies, Bridgetown, Barbados.
Madhuvanti M MurphyFaculty of Medical Sciences, The University of the West Indies, Cave Hill, Barbados.
E Nigel HarrisThe University of the West Indies, Kingston, Jamaica.
Rainford WilksThe University of the West Indies, Kingston, Jamaica.
Marlene MacLeishThe Sullivan Alliance, Alexandria, VA, USA.
Louis SullivanThe Sullivan Alliance, Alexandria, VA, USA.
Natasha Sobers-GrannumFaculty of Medical Sciences, The University of the West Indies, Cave Hill, Barbados.
U.S. Caribbean Alliance for Health Disparities Research Group (USCAHDR)

Funding

The U.S.A-Caribbean Alliance for Health Disparities Research (USACAHDR)U24MD006959 · NIMHD · SULLIVAN ALLIANCE/TRANSFORM/HLTH/PROFESS · PI SULLIVAN, LOUIS W. · 2011 to 2015
$4.6M
NIMHD NIH HHS U24 MD006959
6 · The paper itself

Abstract

backgroundProstate cancer remains the leading cause of cancer deaths among Caribbean men. However, little data exists on the influence of social factors on prostate cancer in the Caribbean setting. This article supports the 2011 Rio Political Declaration on addressing health inequalities by presenting a systematic review of evidence on the role of social determinants on prostate cancer in Caribbean men. It aims to determine the distribution, by known social determinants of health, of the frequency and adverse outcomes of prostate cancer among Caribbean populations.

methodsObservational studies reporting an association between a social determinant and prostate cancer frequency and outcomes were sought in MEDLINE, EMBASE, SciELO, CINAHL, CUMED, LILACS, and IBECS databases. Fourteen social determinants and 7 prostate cancer endpoints were chosen, providing 98 possible relationship groups exploring the role of social determinants on prostate cancer. Observational studies with > 50 participants conducted in Caribbean territories between 2004 and 2016 were eligible. The review was conducted according to STROBE and PRISMA guidelines. Random-effects meta-analyses were performed.

resultsFrom 843 potentially relevant citations, 13 articles from 9 studies were included. From these included studies, 24 relationships were reported looking at 11 distinct relationship groups, leaving 90 relationship groups (92% of all relationship groups) unexplored. Study heterogeneity and risk of bias restricted results to a narrative synthesis in most instances. Meta-analyses showed more diagnosed prostate cancer among men with less formal education (n = 2 studies, OR 1.60, 95%CI 1.18-2.19) and among men who were married (n = 3 studies, OR 1.54, 95%CI 1.22-1.95).

conclusionsThis review highlights limited evidence for a higher occurrence of diagnosed prostate cancer among Caribbean men with lower levels of education and among men who are married. The role of social determinants on prostate cancer among Caribbean men remains poorly understood. Improvements in study quantity and quality, and reduced variability in outcomes and reporting are needed. This report represents the current evidence, and provides a roadmap to future research priorities for a better understanding of Caribbean prostate cancer inequalities.

Indexed as

Health StatusSocial Determinants of HealthAdultAgedAged, 80 and overCaribbean RegionCause of DeathCross-Sectional StudiesEthnicityHumansMaleMiddle AgedPrevalenceProspective StudiesProstatic NeoplasmsRisk FactorsCaribbeanDisparityInequalityProstate cancerSocial determinantsSystematic review

Identifiers

PMID30029628
PMCPMC6053791

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.