Evidence map›Paper›PMID 30029617›Full record

ArticleClinical epigenetics2018

Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes.

Lu Gao, Xiaochen Liu, Joshua Millstein, Kimberly D Siegmund, Louis Dubeau, Rachel L Maguire, Junfeng Jim Zhang, Bernard F Fuemmeler, Scott H Kollins, Cathrine Hoyo and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Are Babies Born Preterm High-Risk Asthma Candidates?Journal of clinical medicine · 2023
    Review
  4. Article
  5. The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Lu GaoDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA, 90032, USA.
Xiaochen LiuDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA, 90032, USA.
Joshua MillsteinDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA, 90032, USA.
Kimberly D SiegmundDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA, 90032, USA.
Louis DubeauDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA, 90032, USA.
Rachel L MaguireDepartment of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27695, USA.
Junfeng Jim ZhangNicholas School of the Environment and Duke Global Health Institute, Duke University, Durham, NC, 27701, USA.
Bernard F FuemmelerDepartment of Health Behavior and Policy, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23219, USA.
Scott H KollinsDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, 27705, USA.
Cathrine HoyoDepartment of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27695, USA.
Susan K MurphyDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, 27708, USA.
Carrie V BretonDepartment of Preventive Medicine, USC Keck School of Medicine, 2001 N. Soto Street, Los Angeles, CA, 90032, USA. breton@usc.edu.
Keck Hospital of USC · USNorth Carolina State University · USDuke University · USDuke University Hospital · USVirginia Commonwealth University · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Project 3: Epigenomic Consequences of Early Life Environmental Tobacco Smoke P01ES022831 · NIEHS · DUKE UNIVERSITY · PI MURPHY, SUSAN KAY · 2013 to 2018
$4.1M
Prenatal Tobacco Smoke, Genetic and Epigenetic Changes, and Respiratory HealthR01ES022216 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2013 to 2016
$2.0M
Smoking/Nicotine Dependence in Attention Deficit Hyperactivity Disorder (ADHD)K24DA023464 · NIDA · DUKE UNIVERSITY · PI KOLLINS, SCOTT H · 2008 to 2018
$1.5M
Prenatal air pollution, DNA methylation and early signs of atherosclerosisK01ES017801 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2010 to 2014
$652k
NIDA NIH HHS K24 DA023464NIEHS NIH HHS K01 ES017801NIEHS NIH HHS P01 ES022831NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES022216
6 · The paper itself

Abstract

backgroundEpigenetic modifications, including DNA methylation, act as one potential mechanism underlying the detrimental effects associated with prenatal tobacco smoke (PTS) exposure. Methylation in a gene called AXL was previously reported to differ in response to PTS.

methodsWe investigated the association between PTS and epigenetic changes in AXL and how this was related to childhood asthma phenotypes. We tested the association between PTS and DNA methylation at multiple CpG loci of AXL at birth using Pyrosequencing in two separate study populations, the Children's Health Study (CHS, n = 799) and the Newborn Epigenetic Study (NEST, n = 592). Plasma cotinine concentration was used to validate findings with self-reported smoking status. The inter-relationships among AXL mRNA and miR-199a1 expression, PTS, and AXL methylation were examined. Lastly, we evaluated the joint effects of AXL methylation and PTS on the risk of asthma and related symptoms at age 10 years old.

resultsPTS was associated with higher methylation level in the AXL gene body in both CHS and NEST subjects. In the pooled analysis, exposed subjects had a 0.51% higher methylation level in this region compared to unexposed subjects (95% CI 0.29, 0.74; p < 0.0001). PTS was also associated with 21.2% lower expression of miR-199a1 (95% CI - 37.9, - 0.1; p = 0.05), a microRNA known to regulate AXL expression. Furthermore, the combination of higher AXL methylation and PTS exposure at birth increased the risk of recent episodes of bronchitic symptoms in childhood.

conclusionsPTS was associated with methylation level of AXL and the combination altered the risk of childhood bronchitic symptoms.

Indexed as

DNA MethylationAsthmaAxl Receptor Tyrosine KinaseChildCotinineEpigenesis, GeneticFemaleGenetic Association StudiesHumansInfant, NewbornMaleMicroRNAsPregnancyPrenatal Exposure Delayed EffectsProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesAXL protein, humanAxl Receptor Tyrosine KinaseCotinineMicroRNAsmirn199 microRNA, humanProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesEpigeneticsMethylationSmoke

Identifiers

PMID30029617
PMCPMC6054742
OpenAlexW2884617790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.