Evidence map›Paper›PMID 30029532›Full record

ArticleMolecules (Basel, Switzerland)2018

Cyclic Octamer Peptoids: Simplified Isosters of Bioactive Fungal Cyclodepsipeptides.

Assunta D'Amato, Giorgio Della Sala, Irene Izzo, Chiara Costabile, Yuichi Masuda, Francesco De Riccardis

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Assunta D'AmatoDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy. asdamato@unisa.it.
Giorgio Della SalaDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy. gdsala@unisa.it.ORCID 0000-0001-5020-8502
Irene IzzoDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy. iizzo@unisa.it.ORCID 0000-0002-0369-0102
Chiara CostabileDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy. ccostabile@unisa.it.
Yuichi MasudaGraduate School of Bioresources, Mie University, 1577 Kurimamachiya-cho, Tsu 514-8507, Japan. masuda@bio.mie-u.ac.jp.
Francesco De RiccardisDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy. dericca@unisa.it.ORCID 0000-0002-8121-9463
University of Salerno · ITMie University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclic peptoids have recently emerged as an important class of bioactive scaffolds with unique conformational properties and excellent metabolic stabilities. In this paper, we describe the design and synthesis of novel cyclic octamer peptoids as simplified isosters of mycotoxin depsipeptides bassianolide, verticilide A1, PF1022A and PF1022B. We also examine their complexing abilities in the presence of sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (TFPB) salt and explore their general insecticidal activity. Finally, we discuss the possible relationship between structural features of free and Na⁺-complexed cyclic octamer peptoids and bioactivities in light of conformational isomerism, a crucial factor affecting cyclic peptoids' biomimetic potentials.

Indexed as

Protein MultimerizationAnimalsBombyxDepsipeptidesFungal ProteinsInsecticidesIsomerismMagnetic Resonance SpectroscopyModels, MolecularMolecular StructureMycotoxinsPeptoidsProtein ConformationStructure-Activity RelationshipDepsipeptidesFungal ProteinsInsecticidesMycotoxinsPeptoidsconformational isomerismcyclic peptoidscyclodepsipeptidesinsecticidal activitypeptidomimeticsstructure-based design

Identifiers

PMID30029532
PMCPMC6100324
OpenAlexW2883735901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.