Evidence map›Paper›PMID 30029513›Full record

ArticleMolecules (Basel, Switzerland)2018

A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant

Javier Campanini-Salinas, Juan Andrades-Lagos, Gerardo Gonzalez Rocha, Duane Choquesillo-Lazarte, Soledad Bollo Dragnic, Mario Faúndez, Pedro Alarcón, Francisco Silva, Roberto Vidal, Edison Salas-Huenuleo and 4 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. New Quinone Antibiotics against Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Javier Campanini-SalinasDrug Development Laboratory, Faculty of Chemical and Pharmaceutical, Sciences, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile. javier.campanini@uss.cl.
Juan Andrades-LagosDrug Development Laboratory, Faculty of Chemical and Pharmaceutical, Sciences, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile. jandrades@ug.uchile.cl.
Gerardo Gonzalez RochaLaboratorio de Investigación en Agentes Antibacterianos (LIAA), Departamento de Microbiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070386, Chile. ggonzal@udec.cl.ORCID 0000-0003-2351-1236
Duane Choquesillo-LazarteLaboratorio de Estudios Cristalográficos, IACT (CSIC-UGR), Av. de las Palmeras 4, 18100 Armilla (Granada), Spain. duane.choquesillo@csic.es.ORCID 0000-0002-7077-8972
Soledad Bollo DragnicBioelectrochemistry Laboratory, Faculty of Chemical and Pharmaceutical, Sciences, Universidad de Chile, Santiago 8380492, Chile. sbollo@ciq.uchile.cl.
Mario FaúndezMolecular Pharmacology and Toxicology Laboratory, Pharmacy Department, Faculty of Chemistry, Pontificia Universidad Católica de Chile; Santiago 7820436, Chile. mfaundeza@uc.cl.
Pedro AlarcónAgents of bacterial meningitis laboratory, Instituto de Salud Pública de Chile, Santiago 7780050, Chile. palarcon@ispch.cl.
Francisco SilvaMicrobiology Unit, Clinical Laboratory, Clinical Hospital University of Chile; Santiago 8380456, Chile. fsilva@hcuch.cl.
Roberto VidalAntibiotics Laboratory, Microbiology Program, Biomedical Sciences Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile. rvidal@uchile.cl.ORCID 0000-0003-4223-1985
Edison Salas-HuenuleoNanobiotechnology and Nanotoxicology Laboratory, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Santiago 8380494, Chile. edison.salash@gmail.com.
Marcelo KoganNanobiotechnology and Nanotoxicology Laboratory, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Santiago 8380494, Chile. mkogan@ciq.uchile.cl.
Jaime MellaInstitute of Chemistry and Biochemistry, Faculty of Sciences, Universidad de Valparaíso, Playa Ancha, Valparaíso 2360102, Chile. jaime.mella@uv.cl.ORCID 0000-0002-2434-8461
Gonzalo Recabarren GajardoLaboratory of Synthesis of Bioactive Heterocycles, Pharmacy Department, Faculty of Chemistry, Pontificia Universidad Católica de Chile; Santiago 7820436, Chile. grecabarren@uc.cl.ORCID 0000-0002-7763-7830
David Vásquez-VelásquezDrug Development Laboratory, Faculty of Chemical and Pharmaceutical, Sciences, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile. dvasquez@ciq.uchile.cl.ORCID 0000-0003-0635-4857

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy of antibiotics and reducing the therapeutic arsenal available for treatment of infectious diseases. In the present study, we developed a new class of compounds with antibacterial activity obtained by a simple, two step synthesis and screened the products for in vitro antibacterial activity against ATCC

Indexed as

Anti-Bacterial AgentsChemical PhenomenaDrug Resistance, Multiple, BacterialEnterococcus faeciumHumansMicrobial Sensitivity TestsModels, MolecularMolecular StructureStaphylococcus aureusStructure-Activity RelationshipX-Ray DiffractionAnti-Bacterial Agentsantibacterial activitymethicillin-resistant Staphylococcus aureusquinonic-antibioticsvancomycin-resistant Enterococcus faecium

Identifiers

PMID30029513
PMCPMC6100241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.