ArticleMolecules (Basel, Switzerland)2018
Protective Mechanism of Sulforaphane on Cadmium-Induced Sertoli Cell Injury in Mice Testis via Nrf2/ARE Signaling Pathway.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Bioactive Compounds Protect Mammalian Reproductive Cells from Xenobiotics and Heat Stress-Induced Oxidative Distress via Nrf2 Signaling Activation: A Narrative Review.Antioxidants (Basel, Switzerland) · 2024Review
- Sulforaphane Exposure Prevents Cadmium-Induced Toxicity and Mitochondrial Dysfunction in the NematodeAntioxidants (Basel, Switzerland) · 2024Article
- Article
- Redox mechanisms of environmental toxicants on male reproductive function.Frontiers in cell and developmental biology · 2024Review
- Zinc restores functionality in porcine prepubertal Sertoli cells exposed to subtoxic cadmium concentrationFrontiers in endocrinology · 2023Article
- Effect of sulforaphane on long-term storage of rabbit semen.Animal reproduction · 2023Article
- Up-regulation of Arl4a gene expression by broccoli aqueous extract is associated with improved spermatogenesis in mouse testes.Biomedica : revista del Instituto Nacional de Salud · 2021Article
- The Role of Toxic Metals and Metalloids in Nrf2 Signaling.Antioxidants (Basel, Switzerland) · 2021Review
- Effects of Titanium Dioxide Nanoparticles on Porcine Prepubertal Sertoli Cells: An "Frontiers in endocrinology · 2021Article
- Article
- Rosa persica hydroalcoholic extract improves cadmium-hepatotoxicity by modulating oxidative damage and tumor necrosis factor-alpha status.Environmental science and pollution research international · 2020Article
- Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method.Molecules (Basel, Switzerland) · 2020Article
- LaInternational journal of nanomedicine · 2020Article
- Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell InjuryFrontiers in pharmacology · 2020Article
- Dexmedetomidine Attenuates Neuroinflammatory-Induced Apoptosis after Traumatic Brain Injury via Nrf2 signaling pathway.Annals of clinical and translational neurology · 2019Article
- Special Issue: The Antioxidant Capacities of Natural Products.Molecules (Basel, Switzerland) · 2019Article
- Proanthocyanidins Antagonize Arsenic-Induced Oxidative Damage and Promote Arsenic Methylation through Activation of the Nrf2 Signaling Pathway.Oxidative medicine and cellular longevity · 2019Article
- Interventions to Address Environmental Metabolism-Disrupting Chemicals: Changing the Narrative to Empower Action to Restore Metabolic Health.Frontiers in endocrinology · 2019Review
- Royal Jelly Abrogates Cadmium-Induced Oxidative Challenge in Mouse Testes: Involvement of the Nrf2 Pathway.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study evaluated the mechanism underlying the protective effect of sulforaphane (SFN) on cadmium (Cd)-induced Sertoli cell (TM4 cells) injury in mice. The apoptosis rate of cells in each group was detected by flow cytometry. It was determined the effect of SFN on the expression of downstream molecular targets of Nrf2/ARE axis and on the lipid peroxide content. The related genes involved in the nuclear factor E2-related factor 2(Nrf2)/antioxidant response element (ARE) signaling pathway were evaluated by RT-PCR; for example, the mRNA expression levels of Nrf2, heme oxygenase-1 (HO-1), glutathione peroxidase (GSH-Px), quinone oxidoreductase 1 (NQO1), and γ-glutamylcysteine synthetase (γ-GCS), while the protein expression levels were assessed by Western blot. Our results showed that the mRNA and protein expression levels of Nrf2, HO-1, NQO1, GSH-Px, and γ-GCS were increased in various degree when the Sertoli cells were to added different concentrations of SFN. Our results also showed that SFN reduced the apoptosis rate, increased the activity of T-SOD, inhibited the increase of the MDA content caused by Cd. Meanwhile, SFN could increase the mRNA and protein expression levels of Nrf2, HO-1 and NQO1 and reduced the mRNA and protein expression levels of GSH-Px and γ-GCS caused by Cd in Sertoli cells (
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