ArticleJournal of biomechanical engineering2018
Numerical Parametric Study of Paravalvular Leak Following a Transcatheter Aortic Valve Deployment Into a Patient-Specific Aortic Root.
Article in Journal of biomechanical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
- Feasibility of large-scale in silico transcatheter aortic valve implantation trials using a fast-to-evaluate model.Biomechanics and modeling in mechanobiology · 2026Article
- Computational modelling for personalized transcatheter aortic valve replacement planning: a systematic review of complications and decision support.Frontiers in digital health · 2026Review
- Predicting procedural outcomes in transcatheter aortic valve implantation: a scoping review of numerical patient-specific simulations.Progress in biomedical engineering (Bristol, England) · 2025Article
- Advanced Computer Simulation Based on Cardiac Imaging in Planning of Structural Heart Disease Interventions.Journal of clinical medicine · 2025Review
- Robust automated calcification meshing for personalized cardiovascular biomechanics.NPJ digital medicine · 2024Article
- Fluid-Solid Interaction Analysis for Developing In-Situ Strain and Flow Sensors for Prosthetic Valve Monitoring.Sensors (Basel, Switzerland) · 2024Article
- On the Material Constitutive Behavior of the Aortic Root in Patients with Transcatheter Aortic Valve Implantation.Cardiovascular engineering and technology · 2024Article
- Parameterization, algorithmic modeling, and fluid-structure interaction analysis for generative design of transcatheter aortic valves.Engineering with computers · 2024Article
- Patient-Specific Heart Geometry Modeling for Solid Biomechanics Using Deep Learning.IEEE transactions on medical imaging · 2024Article
- Latest Developments in Adapting Deep Learning for Assessing TAVR Procedures and Outcomes.Journal of clinical medicine · 2023Review
- Long-term prognostic impact of paravalvular leakage on coronary artery disease requires patient-specific quantification of hemodynamics.Scientific reports · 2022Article
- Validating In Silico and In Vitro Patient-Specific Structural and Flow Models with Transcatheter Bicuspid Aortic Valve Replacement Procedure.Cardiovascular engineering and technology · 2022Article
- Leaflet Stresses During Full Device Simulation of Crimping to 6 mm in Transcatheter Aortic Valve Implantation, TAVI.Cardiovascular engineering and technology · 2022Article
- Biomechanics of Transcatheter Aortic Valve Implant.Bioengineering (Basel, Switzerland) · 2022Review
- Transcatheter aortic valve replacement for bicuspid aortic valve disease: does conventional surgery have a future?Annals of cardiothoracic surgery · 2022Review
- A computational framework for post-TAVR cardiac conduction abnormality (CCA) risk assessment in patient-specific anatomy.Artificial organs · 2022Article
- Biomechanics of Transcatheter Aortic Valve Replacement Complications and Computational Predictive Modeling.Structural heart : the journal of the Heart Team · 2022Review
- Treatment of Bicuspid Aortic Valve Stenosis with TAVR: Filling Knowledge Gaps Towards Reducing Complications.Current cardiology reports · 2022Review
- Assessing the Hemodynamic Impact of Anterior Leaflet Laceration in Transcatheter Mitral Valve Replacement: AnFrontiers in cardiovascular medicine · 2022Article
- Application of physics-based flow models in cardiovascular medicine: Current practices and challenges.Biophysics reviews · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Paravalvular leak (PVL) is a relatively frequent complication after transcatheter aortic valve replacement (TAVR) with increased mortality. Currently, there is no effective method to pre-operatively predict and prevent PVL. In this study, we developed a computational model to predict the severity of PVL after TAVR. Nonlinear finite element (FE) method was used to simulate a self-expandable CoreValve deployment into a patient-specific aortic root, specified with human material properties of aortic tissues. Subsequently, computational fluid dynamics (CFD) simulations were performed using the post-TAVR geometries from the FE simulation, and a parametric investigation of the impact of the transcatheter aortic valve (TAV) skirt shape, TAV orientation, and deployment height on PVL was conducted. The predicted PVL was in good agreement with the echocardiography data. Due to the scallop shape of CoreValve skirt, the difference of PVL due to TAV orientation can be as large as 40%. Although the stent thickness is small compared to the aortic annulus size, we found that inappropriate modeling of it can lead to an underestimation of PVL up to 10 ml/beat. Moreover, the deployment height could significantly alter the extent and the distribution of regurgitant jets, which results in a change of leaking volume up to 70%. Further investigation in a large cohort of patients is warranted to verify the accuracy of our model. This study demonstrated that a rigorously developed patient-specific computational model can provide useful insights into underlying mechanisms causing PVL and potentially assist in pre-operative planning for TAVR to minimize PVL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.