ArticleJournal of biomechanical engineering2018
Statistical Characterization of Human Brain Deformation During Mild Angular Acceleration Measured In Vivo by Tagged Magnetic Resonance Imaging.
Article in Journal of biomechanical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05675423 (Imaging Characterization of the Biomechanical Coupling of Brain and Skull), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Imaging Characterization of the Biomechanical Coupling of Brain and Skull: An Observational Study
Who cites it
20 citing papers in PubMed.
- In Vivo Brain Deformation in a Sheep Model of Rapid Head Rotation.Annals of biomedical engineering · 2026Article
- Brain-Adhesive Bioelectronics With Shape-Morphable and Biodegradable Properties for Stable Brain Signal Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Average Biomechanical Responses of the Human Brain Grouped by Age and Sex.Annals of biomedical engineering · 2025Article
- A Novel Experimental Approach for the Measurement of Vibration-Induced Changes in the Rheological Properties of Ex Vivo Ovine Brain Tissue.Sensors (Basel, Switzerland) · 2024Article
- Magnetic Resonance Elastography-Based Technique to Assess the Biomechanics of the Skull-Brain Interface: Repeatability and Age-Sex Characteristics.Journal of neurotrauma · 2023Article
- Article
- Characterization of material properties and deformation in the ANGUS phantom during mild head impacts using MRI.Journal of the mechanical behavior of biomedical materials · 2023Article
- Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports.Annals of biomedical engineering · 2022Review
- MR Imaging of Human Brain Mechanics In Vivo: New Measurements to Facilitate the Development of Computational Models of Brain Injury.Annals of biomedical engineering · 2021Review
- Evaluation of Tissue-Level Brain Injury Metrics Using Species-Specific Simulations.Journal of neurotrauma · 2021Article
- Group characterization of impact-induced,Journal of the Royal Society, Interface · 2021Article
- Instantaneous Whole-Brain Strain Estimation in Dynamic Head Impact.Journal of neurotrauma · 2021Article
- Natural oscillatory modes of 3D deformation of the human brain in vivo.Journal of biomechanics · 2021Article
- Mechanosensation in traumatic brain injury.Neurobiology of disease · 2021Review
- Integrating material properties from magnetic resonance elastography into subject-specific computational models for the human brain.Brain multiphysics · 2021Article
- A machine learning approach for magnetic resonance image-based mouse brain modeling and fast computation in controlled cortical impact.Medical & biological engineering & computing · 2020Article
- In vivo estimates of axonal stretch and 3D brain deformation during mild head impact.Brain multiphysics · 2020Article
- Mechanisms of Local Stress Amplification in Axons near the Gray-White Matter Interface.Biophysical journal · 2020Article
- Displacement- and Strain-Based Discrimination of Head Injury Models across a Wide Range of Blunt Conditions.Annals of biomedical engineering · 2020Article
- Article
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Authors and funding
9 authors.
Funding
Abstract
Understanding of in vivo brain biomechanical behavior is critical in the study of traumatic brain injury (TBI) mechanisms and prevention. Using tagged magnetic resonance imaging, we measured spatiotemporal brain deformations in 34 healthy human volunteers under mild angular accelerations of the head. Two-dimensional (2D) Lagrangian strains were examined throughout the brain in each subject. Strain metrics peaked shortly after contact with a padded stop, corresponding to the inertial response of the brain after head deceleration. Maximum shear strain of at least 3% was experienced at peak deformation by an area fraction (median±standard error) of 23.5±1.8% of cortical gray matter, 15.9±1.4% of white matter, and 4.0±1.5% of deep gray matter. Cortical gray matter strains were greater in the temporal cortex on the side of the initial contact with the padded stop and also in the contralateral temporal, frontal, and parietal cortex. These tissue-level deformations from a population of healthy volunteers provide the first in vivo measurements of full-volume brain deformation in response to known kinematics. Although strains differed in different tissue type and cortical lobes, no significant differences between male and female head accelerations or strain metrics were found. These cumulative results highlight important kinematic features of the brain's mechanical response and can be used to facilitate the evaluation of computational simulations of TBI.
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Registered trials
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