Evidence map›Paper›PMID 30029227›Full record

ArticleJournal of vision2018

Human infants can generate vergence responses to retinal disparity by 5 to 10 weeks of age.

Eric S Seemiller, Bruce G Cumming, T Rowan Candy

Abstract read
In one paragraph

Article in Journal of vision, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Neural Control of Vergence and Ocular Accommodation.Annual review of vision science · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eric S SeemillerIndiana University School of Optometry, Bloomington, IN, USA.
Bruce G CummingLaboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
T Rowan CandyIndiana University School of Optometry, Bloomington, IN, USA.

Funding

Multi-Center Uveitis Steriod Treatment (MUST) TrialU10EY014660 · NEI · JOHNS HOPKINS UNIVERSITY · PI HOLBROOK, JANET T. · 2004 to 2016
$33.6M
Role Of Visual Cortex In Depth PerceptionZIAEY000404 · NEI · NATIONAL EYE INSTITUTE · PI CUMMING, BRUCE G · 2009 to 2021
$27.9M
Accommodation and Defocus in the Infant Visual SystemR01EY014460 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI CANDY, T ROWAN · 2003 to 2025
$7.5M
Core Support for Vision Research at Indiana UniversityP30EY019008 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI BURNS, STEPHEN A · 2009 to 2013
$2.1M
NEI NIH HHS P30 EY019008NEI NIH HHS R01 EY014460NEI NIH HHS U10 EY014660
6 · The paper itself

Abstract

Vergence is defined as a binocular eye movement during which the two eyes move in opposite directions to align to a target in depth. In adults, fine vergence control is driven primarily by interocular retinal image disparity. Although infants have not typically been shown to respond to disparity until 3 to 5 months postpartum, they have been shown to align their eyes from hours after birth. It remains unclear what drives these responses in young infants. In this experiment, 5- to 10-week-old human infants were presented with a dynamic random noise stimulus oscillating in disparity at 0.1 Hz over an amplitude of 2° for 30 s. Fourier transforms of the horizontal eye movements revealed significant disparity-driven responses at the frequency of the stimulus in over half of the tested infants. Because the stimulus updated dynamically, this experiment precluded the possibility of independent monocular fixations to a sustained target. These data demonstrate cortical binocular function in humans by five weeks, the youngest age tested here, which is as much as two months younger than previously believed.

Indexed as

AdultAgingConvergence, OcularEye MovementsFemaleHumansInfantMalePresbyopiaVision, BinocularVision Disparity

Identifiers

PMID30029227
PMCPMC6025847

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.