SynthesisCancer epidemiology2018
Obesity and renal cell carcinoma risk by histologic subtype: A nested case-control study and meta-analysis.
Synthesis in Cancer epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Variation in image-assessed abdominal adiposity and skeletal muscle and their associations with pathological characteristics in renal cell carcinoma.Cancer causes & control : CCC · 2026Article
- Review
- Using Mendelian randomization to investigate etiologic heterogeneity across renal cell carcinoma subtypes.International journal of epidemiology · 2025Article
- The prognostic value of adipokine receptors leptinR and adiponectinR1 in obesity-inducible solid tumours.Histology and histopathology · 2025Article
- The relationship between renal cell carcinoma pathological types and perirenal fat area.BMC cancer · 2025Article
- Body mass index and risk of over 100 cancer forms and subtypes in 4.1 million individuals in Sweden: the Obesity and Disease Development Sweden (ODDS) pooled cohort study.The Lancet regional health. Europe · 2024Article
- Global burden of benign prostatic hyperplasia, urinary tract infections, urolithiasis, bladder cancer, kidney cancer, and prostate cancer from 1990 to 2021.Military Medical Research · 2024Article
- Prediction of Fuhrman nuclear grade for clear cell renal carcinoma by a multi-information fusion model that incorporates CT-based features of tumor and serum tumor associated material.Journal of cancer research and clinical oncology · 2023Article
- Recent Advances in the Management of Clear Cell Renal Cell Carcinoma: Novel Biomarkers and Targeted Therapies.Cancers · 2023Review
- Clear cell renal cell carcinoma molecular variations in non-Hispanic White and Hispanic patients.Cancer medicine · 2023Article
- Heart Metastases of Clear Cell Renal Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2023Article
- Associations of Renal Cell Carcinoma Subtype with Patient Demographics, Comorbidities, and Neighborhood Socioeconomic Status in the California Population.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation.British journal of cancer · 2023Article
- Body mass index and waist circumference in relation to the risk of 26 types of cancer: a prospective cohort study of 3.5 million adults in Spain.BMC medicine · 2021Article
- The Potential of Visceral Adipose Tissue in Distinguishing Clear Cell Renal Cell Carcinoma from Renal Angiomyolipoma with Minimal Fat.Cancer management and research · 2021Article
- Patterns of distant metastases in patients with clear cell renal cell carcinoma--A population-based analysis.Cancer medicine · 2021Article
- Etiologic heterogeneity of clear-cell and papillary renal cell carcinoma in the Netherlands Cohort Study.International journal of cancer · 2021Article
- Renal cell carcinoma: Associations between tumor imaging features and epidemiological risk factors.European journal of radiology · 2020Article
- Epidemiology of Renal Cell Carcinoma.World journal of oncology · 2020Review
- Early life body size in relation to risk of renal cell carcinoma in adulthood: a Danish observational cohort study.European journal of epidemiology · 2020Observational
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAlthough obesity is an established risk factor for renal cell carcinoma (RCC), it is unclear whether this relationship varies across histologic subtypes.
methodsWe conducted a nested case-control study within the Kaiser Permanente Northern California (KPNC) health care network, and meta-analysis combining our results with those of previously published studies. Our KPNC study included 685 RCC cases [421 clear cell; 65 papillary; 24 chromophobe; 35 other; 141 not otherwise specified (NOS)] and 4266 controls. Subtype-specific odds ratios (ORs) and 95% confidence intervals (CIs) for categories of body mass index (BMI) and were computed from the case-control data using polytomous logistic regression. Findings from this and other relevant studies were combined by meta-analysis using a random effects model.
resultsIn the KPNC study, obesity (BMI ≥ 30 kg/m
conclusionsThese findings support the hypothesis that histologic subtypes of RCC possess distinct etiologic pathways, with obesity important for the development of clear cell and, possibly, chromophobe RCC, but not papillary RCC.
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