Evidence map›Paper›PMID 30029051›Full record

ArticleJournal of psychiatric research2018

Which levels of cognitive impairments and negative symptoms are related to functional deficits in schizophrenia?

M Strassnig, C Bowie, A E Pinkham, D Penn, Elizabeth W Twamley, Thomas L Patterson, P D Harvey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  5. European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M StrassnigDepartment of Integrated Medical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Road Boca Raton, FL, 33431, USA. Electronic address: mstrassnig@health.fau.edu.
C BowieDepartment of Psychology, Queen's University, Kingston, ON, USA.
A E PinkhamSchool of Behavior and Brain Science, University of Texas at Dallas, Dallas, TX, USA.
D PennDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Elizabeth W TwamleyDepartment of Psychiatry, University of California at San Diego, San Diego, CA, USA.
Thomas L PattersonDepartment of Psychiatry, University of California at San Diego, San Diego, CA, USA.
P D HarveyDepartment of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL, USA; Research Services, Bruce V. Carter VA, Miami, FL, USA.

Funding

Validation of Measures of real-world outcomeR01MH078775 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARVEY, PHILIP D. · 2007 to 2011
$1.7M
NIMH NIH HHS R01 MH078775
6 · The paper itself

Abstract

backgroundNegative symptoms and cognitive impairments predict difficulties in aspects of everyday functioning in schizophrenia, with little research to date attempting to determine if there are threshold levels of impairment required to predict the severity of functional deficits.

methodsPeople diagnosed with chronic schizophrenia (n = 821) were assessed with the MCCB and PANSS, and rated by high contact informants with SLOF. Negative symptoms of reduced emotional experience were specifically targeted for analysis because of their previously identified relationships with social outcomes. We identified patients with moderate negative symptoms (at least one PANSS item ≥4) versus less severe symptoms (PANSS items ≤3) and divided patients on the basis of a single latent-trait global cognition score (neuropsychologically normal vs neuropsychologically impaired; performance at or below 1.0 SD from the normative population mean, T = 40), then examined correlations between cognition, negative symptoms and everyday functioning in the groups with lower and higher negative symptoms and those with/without cognitive impairment.

resultsEven low levels of negative symptoms were correlated with ratings of social functioning. Cognitive performance in the neuropsychologically normal range, in contrast, was not correlated with any aspects of everyday functioning while more impaired performance predicted greater functional impairments.

conclusionsEven minimal symptoms may be a target for clinical attention in the domains of negative symptoms, consistent with previous findings regarding social deficits in populations with modest negative symptoms (e.g., schizotypal personality disorder). Cognitive rehabilitation treatments might not improve social functioning if even low levels of negative symptoms (social amotivation) are present.

Indexed as

Schizophrenic PsychologyAdultAffective SymptomsAgedCognition DisordersCohort StudiesFemaleHumansMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesSchizophrenia

Identifiers

PMID30029051
PMCPMC13016699

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.