ArticleMultiple sclerosis and related disorders2018
An MRI evaluation of grey matter damage in African Americans with MS.
Article in Multiple sclerosis and related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Gray Matter Atrophy in the Cortico-Striatal-Thalamic Network and Sensorimotor Network in Relapsing-Remitting and Primary Progressive Multiple Sclerosis.Neuropsychology review · 2021Pooled it
- Structure-Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS.Annals of clinical and translational neurology · 2026Article
- The hidden toll: Atrophy of key central nervous system relays in African American women with multiple sclerosis.Journal of neuroimmunology · 2025Article
- Mapping tissue microstructure across the human brain on a clinical scanner with soma and neurite density image metrics.Human brain mapping · 2023Article
- Do magnetic resonance imaging features differ between persons with multiple sclerosis of various races and ethnicities?Frontiers in neurology · 2023Review
- Cerebellar pathology in multiple sclerosis and experimental autoimmune encephalomyelitis: current status and future directions.Journal of central nervous system disease · 2023Review
- Disability outcomes in early-stage African American and White people with multiple sclerosis.Multiple sclerosis and related disorders · 2023Article
- Understanding humoral immunity and multiple sclerosis severity in Black, and Latinx patients.Frontiers in immunology · 2023Review
- Classification of multiple sclerosis patients based on structural disconnection: A robust feature selection approach.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Review
- Sensory-motor network topology in multiple sclerosis: Structural connectivity analysis accounting for intrinsic density discrepancy.Human brain mapping · 2020Article
- Efficacy and Safety of Alemtuzumab in Patients of African Descent with Relapsing-Remitting Multiple Sclerosis: 8-Year Follow-up of CARE-MS I and II (TOPAZ Study).Neurology and therapy · 2019Article
- Diversity, Equity, and Inclusion in the Multiple Sclerosis Community: A Call to Action.International journal of MS careArticle
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveMultiple sclerosis (MS) is less prevalent in African Americans (AAs) than Caucasians (CAs) but in the former the disease course tends to be more severe. In order to clarify the MRI correlates of disease severity in AAs, we performed a multimodal brain MRI study to comprehensively assess the extent of grey matter (GM) damage and the degree of functional adaptation to structural damage in AAs with MS.
methodsIn this cross-sectional study, we characterized GM damage in terms of focal lesions and volume loss and functional adaptation during the execution of a simple motor task on a sample of 20 AAs and 20 CAs with MS and 20 healthy controls (CTRLs).
resultsIn AAs, we observed a wider range of EDSS scores than CAs, with multisystem involvement being more likely in AAs (p < 0.01). While no significant differences were detected in lesion loads and global brain volumes, AAs showed regional atrophy in the posterior lobules of cerebellum, temporo-occipital and frontal regions in comparison with CAs (p < 0.01), with cerebellar atrophy being the best metric in differentiating AAs from CAs (p = 0.007, AUC = 0.96 and p = 0.005, AUC = 0.96, respectively for right and left cerebellar clusters). In AAs, the functional analysis of cortical activations showed an increase in task-related activation of areas involved in high level processing and a decreased activation in the medial prefrontal cortex compared to CAs.
interpretationIn our study, the direct comparison of AAs and CAs points to cerebellar atrophy as the main difference between subgroups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.