ArticlePloS one2018
Genome-wide association studies of inflammatory bowel disease in German shepherd dogs.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Genetic Regulation of Immune Response in Dogs.Genes · 2025Review
- Ginseng polysaccharides ameliorate DSS-induced inflammatory bowel disease by regulating gut microbiota in dogs.Frontiers in veterinary science · 2025Article
- Targeted next-generation sequencing of candidate regions identified by GWAS revealed SNPs associated with IBD in GSDs.Frontiers in veterinary science · 2025Article
- The effect of puppyhood and adolescent diet on the incidence of chronic enteropathy in dogs later in life.Scientific reports · 2023Article
- Characterization of the Fecal and Mucosa-Associated Microbiota in Dogs with Chronic Inflammatory Enteropathy.Animals : an open access journal from MDPI · 2023Article
- An initial genome-wide investigation of protein-losing enteropathy in Gordon setters: Exploratory observations.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Early Life Modifiable Exposures and Their Association With Owner Reported Inflammatory Bowel Disease Symptoms in Adult Dogs.Frontiers in veterinary science · 2021Article
- Dysbiosis in a canine model of human fistulizing Crohn's disease.Gut microbes · 2020Article
- Natural Infection withmSphere · 2020Article
- Association of Common Genetic Variants in theGenes · 2020Article
- Article
- Genome-wide association studies and genetic testing: understanding the science, success, and future of a rapidly developing field.Journal of the American Veterinary Medical Association · 2019Review
- Genome-wide association studies of 74 plasma metabolites of German shepherd dogs reveal two metabolites associated with genes encoding their enzymes.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids.Microbiome · 2019Article
- Interleukin-13 and interleukin-33 mRNA are underexpressed in the duodenal mucosa of German Shepherd dogs with chronic enteropathy.Journal of veterinary internal medicine · 2019Article
- Article
- Humoral immune responses against gut bacteria in dogs with inflammatory bowel disease.PloS one · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Canine Inflammatory Bowel Disease (IBD) is considered a multifactorial disease caused by complex interactions between the intestinal immune system, intestinal microbiota and environmental factors in genetically susceptible individuals. Although IBD can affect any breed, German shepherd dogs (GSD) in the UK are at increased risk of developing the disease. Based on previous evidence, the aim of the present study was to identify single nucleotide polymorphisms (SNPs), which may confer genetic susceptibility or resistance to IBD using a genome-wide association study (GWAS). Genomic DNA was extracted from EDTA blood or saliva samples of 96 cases and 98 controls. Genotyping of cases and controls was performed on the Canine Illumina HD SNP array and data generated was analyzed using PLINK. Several SNPs and regions on chromosomes 7,9,11 and 13 were detected to be associated with IBD using different SNP-by-SNP association methods and FST windows approach. Searching one Mb up-and down-stream of the most significant SNPs, as identified by single SNP analysis as well as 200Kb before and after the start and the end position of the associated regions identified by FST windows approach, we identified 63 genes. Using a combination of pathways analysis and a list of genes that have been reported to be involved in human IBD, we identified 16 candidate genes potentially associated with IBD in GSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.