ArticlePain2018
Long-term changes in biopsychosocial characteristics related to temporomandibular disorder: findings from the OPPERA study.
Article in Pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05162027 (Erenumab as a Therapeutic Approach for the Management of Painful Chronic Temporomandibular Disorders), which is not on this map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Erenumab as a Therapeutic Approach for the Management of Painful Chronic Temporomandibular Disorders (TMD)
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Psychosocial factors as predictors of headache chronification: A systematic review and meta-analysis of longitudinal studies.Headache · 2026Pooled it
- Pooled it
- Self-Management Therapies for Temporomandibular Disorders-Evidence From Systematic Reviews.Journal of oral rehabilitation · 2026Pooled it
- Temporomandibular Disorders Diagnosis: Current Challenges and the Promising Role of Artificial Intelligence.European journal of dentistry · 2026Article
- Hypnosis and relaxation techniques in the management of temporomandibular disorders: a scoping review.Journal of oral & facial pain and headache · 2026Article
- Artificial intelligence-based prognostic modeling in temporomandibular disorders and chronic orofacial pain: a critical conceptual review.Journal of oral & facial pain and headache · 2026Review
- Comorbid Insomnia and Sleep-Disordered Breathing in Painful Temporomandibular Disorders: Association With Pain Intensity.Journal of oral rehabilitation · 2026Article
- Brief Diagnostic Criteria for Temporomandibular Disorders (Tmd): Enhancing Sensitivity in Diagnosing Headache Attributed to Tmd (A Multi-Centre Study).Journal of oral rehabilitation · 2026Article
- Five-Year Follow-Up of Patients with Persistent Painful Temporomandibular Disorder After Multidisciplinary Assessment.Journal of pain research · 2026Article
- Goat temporomandibular joint osteochondral defects for future regenerative studies of osteoarthritis-like degeneration.PloS one · 2026Article
- Exploring New Frontiers: A Cross-Sectional Analysis of Explosive Phase and Muscle Activation During Maximal Biting in Women with Temporomandibular Disorder and Orofacial Pain.Medical sciences (Basel, Switzerland) · 2025Article
- The Interplay of Orofacial Morphology, Gonial Angle, and Emotional Regulation in Speech and Functional TMJ Impairment and Personalized Approaches.Medicina (Kaunas, Lithuania) · 2025Observational
- Brief Diagnostic Criteria for Temporomandibular Disorders: Sensitivity and Specificity of Clinical Diagnoses (A Multi-Center Study).Journal of oral rehabilitation · 2025Article
- Clinical, psychological, and hematological factors predicting sleep bruxism in patients with temporomandibular disorders.Scientific reports · 2025Observational
- Mapping the Global Landscape of Temporomandibular Disorders Research in Children and Adolescents From 2000 to 2024: A Bibliometric Analysis.Pain research & management · 2025Review
- Recent advances and educational strategies in diagnostic imaging for temporomandibular disorders: a narrative literature review.Frontiers in neurology · 2025Review
- Association between circulating inflammatory proteins and temporomandibular disorders: insight from a two-sample Mendelian randomization analysis.Journal of applied oral science : revista FOB · 2025Article
- Prevalence of central sensitization and somatization in adults with temporomandibular disorders-a prospective observational study.Journal of oral & facial pain and headache · 2024Observational
- Tell me what to expect: how instructions affect the pain response of patients with chronic myofascial pain with referral.Journal of oral & facial pain and headache · 2024Article
- Exploring the causal effects of sleep characteristics on TMD-related pain: a two-sample Mendelian randomization study.Clinical oral investigations · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Painful temporomandibular disorders (TMDs) are both consequence and cause of change in multiple clinical, psychosocial, and biological factors. Although longitudinal studies have identified antecedent biopsychosocial factors that increase risk of the TMD onset and persistence, little is known about long-term change in those factors after TMD develops or remits. During a 7.6-year median follow-up period, we measured change in psychosocial characteristics, pain sensitivity, cardiovascular indicators of autonomic function, and clinical jaw function among 189 participants whose baseline chronic TMD status either persisted or remitted and 505 initially TMD-free participants, 83 of whom developed TMD. Among initially TMD-free participants who developed TMD, symptoms and pain sensitivity increased, whereas psychological function worsened. By contrast, participants with chronic TMD at baseline tended to show improved TMD symptoms, improved jaw function, reduced somatic symptoms, and increased positive affect. In general, clinical and psychosocial variables more frequently changed in parallel with TMD status compared with pain sensitivity and autonomic measures. These findings demonstrate a complex pattern of considerable changes in biopsychosocial function associated with changes in TMD status. In particular, several biopsychosocial parameters improved among participants with chronic TMD despite pain persisting for years, suggesting considerable potential for ongoing coping and adaptation in response to persistent pain.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.