Evidence map›Paper›PMID 30028590›Full record

ArticleACS nano2018

Crystalline Cyclophane-Protein Cage Frameworks.

Ngong Kodiah Beyeh, Nonappa, Ville Liljeström, Joona Mikkilä, Antti Korpi, Davide Bochicchio, Giovanni M Pavan, Olli Ikkala, Robin H A Ras, Mauri A Kostiainen

Open access · hybridAbstract read
In one paragraph

Article in ACS nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Inverse Design of DNA-Programmable Protein Colloidal Crystals.Journal of the American Chemical Society · 2025
    Article
  3. Protein Cage Directed Assembly of Binary Nanoparticle Superlattices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Protein Assembly by Design.Chemical reviews · 2021
    Review
  10. Article
  11. ACS omega · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Ngong Kodiah BeyehHYBER Centre of Excellence, Department of Applied Physics , Aalto University , FI-00076 Aalto , Finland.ORCID 0000-0003-3935-1812
NonappaHYBER Centre of Excellence, Department of Applied Physics , Aalto University , FI-00076 Aalto , Finland.ORCID 0000-0002-6804-4128
Ville LiljeströmHYBER Centre of Excellence, Department of Applied Physics , Aalto University , FI-00076 Aalto , Finland.
Joona MikkiläDepartment of Bioproducts and Biosystems , Aalto University , FI-00076 Aalto , Finland.
Antti KorpiDepartment of Bioproducts and Biosystems , Aalto University , FI-00076 Aalto , Finland.
Davide BochicchioDepartment of Innovative Technologies , University of Applied Sciences and Arts of Southern Switzerland , CH-6928 Manno , Switzerland.ORCID 0000-0002-3682-9086
Giovanni M PavanDepartment of Innovative Technologies , University of Applied Sciences and Arts of Southern Switzerland , CH-6928 Manno , Switzerland.ORCID 0000-0002-3473-8471
Olli IkkalaHYBER Centre of Excellence, Department of Applied Physics , Aalto University , FI-00076 Aalto , Finland.ORCID 0000-0002-0470-1889
Robin H A RasHYBER Centre of Excellence, Department of Applied Physics , Aalto University , FI-00076 Aalto , Finland.ORCID 0000-0002-2076-242X
Mauri A KostiainenHYBER Centre of Excellence, Department of Applied Physics , Aalto University , FI-00076 Aalto , Finland.ORCID 0000-0002-8282-2379
Aalto University · FIUniversity of Applied Sciences and Arts of Southern Switzerland · CHOakland University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclophanes are macrocyclic supramolecular hosts famous for their ability to bind atomic or molecular guests via noncovalent interactions within their well-defined cavities. In a similar way, porous crystalline networks, such as metal-organic frameworks, can create microenvironments that enable controlled guest binding in the solid state. Both types of materials often consist of synthetic components, and they have been developed within separate research fields. Moreover, the use of biomolecules as their structural units has remained elusive. Here, we have synthesized a library of organic cyclophanes and studied their electrostatic self-assembly with biological metal-binding protein cages (ferritins) into ordered structures. We show that cationic pillar[5]arenes and ferritin cages form biohybrid cocrystals with an open protein network structure. Our cyclophane-protein cage frameworks bridge the gap between molecular frameworks and colloidal nanoparticle crystals and combine the versatility of synthetic supramolecular hosts with the highly selective recognition properties of biomolecules. Such host-guest materials are interesting for porous material applications, including water remediation and heterogeneous catalysis.

Indexed as

CrystallizationEthers, CyclicFerritinsMetal-Organic FrameworksModels, MolecularParticle SizePorositySurface PropertiesEthers, CyclicFerritinsMetal-Organic Frameworkscrystalcyclophaneelectrostatic bindingpillarareneprotein cageself-assembly

Identifiers

PMID30028590
PMCPMC6150715
OpenAlexW2883680429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.