Evidence map›Paper›PMID 30028529›Full record

ArticleMuscle & nerve2019

Muscle endurance deficits in myositis patients despite normal manual muscle testing scores.

David R Amici, Iago Pinal-Fernandez, Ruben Pagkatipunan, Albert Mears, Rebecca de Lorenzo, Eleni Tiniakou, Jemima Albayda, Julie J Paik, Thomas E Lloyd, Lisa Christopher-Stine and 2 more

Abstract read
In one paragraph

Article in Muscle & nerve, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Therapeutic management of immune-mediated necrotizing myositis.Current treatment options in rheumatology · 2021
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David R AmiciMuscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Iago Pinal-FernandezMuscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Ruben PagkatipunanJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Albert MearsJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rebecca de LorenzoMuscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Eleni TiniakouJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jemima AlbaydaJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Julie J PaikJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Thomas E LloydJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Lisa Christopher-StineJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Andrew L MammenMuscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Tae ChungJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

Clinical Support Services for the NIAMS Intramural Research ProgramZIDAR041180 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI COLBERT, ROBERT · 2009 to 2025
$119.2M
Rehabilitation Medicine Scientist Training (RMST) ProgramK12HD001097 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BONINGER, MICHAEL L. · 1995 to 2016
$14.1M
Nucleocytoplasmic transport and nuclear pore disruption in ALS/FTDR01NS094239 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LLOYD, THOMAS E., ROTHSTEIN, JEFFREY D · 2016 to 2020
$3.4M
Dynactin function in axons, synapses, and neurodegenerative diseaseR01NS082563 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LLOYD, THOMAS E. · 2013 to 2017
$1.8M
Alteration of kynurenine pathway in age-associated muscle weaknessK08AG058483 · NIA · JOHNS HOPKINS UNIVERSITY · PI CHUNG, TAE HWAN · 2018 to 2022
$854k
Huayi and Siuling Zhang Discovery Fund (to L.C.-S.NIA NIH HHS K08 AG058483NICHD NIH HHS K12 HD001097NIH HHS NS094239 to T.E.L.NIH HHS R01 NS082563NINDS NIH HHS R01 NS082563NINDS NIH HHS R01 NS094239Rehabilitation Medicine Scientist Program NIH 5K12HD001097-19 to T.C.The Myositis Association (to I.P.-F.)
6 · The paper itself

Abstract

introductionIt is unclear whether quantitating muscle endurance adds nonredundant information useful for the care of patients with muscular disease.

methodsRecords were retrospectively reviewed for all Johns Hopkins Myositis Center patients with a muscle endurance assessment (n = 128, 226 patient-visits). Muscle endurance and strength were quantitated with the Myositis Functional Index-2 (FI2) and manual muscle testing (MMT), respectively.

resultsComposite FI2 muscle endurance scores were comparable in inclusion body myositis (n = 58), dermatomyositis (n = 31), and polymyositis (n = 39). Overall, muscle endurance correlated with and evolved similarly to strength, inversely to serum creatine kinase. However, in patients with normal or near-normal strength (mean MMT > 9.75/10), muscle endurance was typically abnormal and highly variable (mean FI2, 5.6/10; interquartile range, 3.3-7.8/10). DISCUSSION: Muscle endurance testing may identify muscle impairment inadequately described by MMT, particularly in patients with high MMT scores. Muscle Nerve 59:70-75, 2019.

Indexed as

AgedCreatine KinaseDermatomyositisFemaleHumansMaleMiddle AgedMuscle StrengthMyositisMyositis, Inclusion BodyPhysical EndurancePolymyositisRetrospective StudiesSeverity of Illness IndexTime FactorsCreatine Kinasefunctional indexmuscle strengthmyositisneuromuscular diseasesphysical endurance

Identifiers

PMID30028529
PMCPMC7951326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.