ArticleLupus2018
Antiphospholipid antibodies in women with severe preeclampsia and placental insufficiency: a case-control study.
Article in Lupus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Antiphospholipid syndrome: epidemiology and outcomes in the evolving criteria era.Nature reviews. Rheumatology · 2026Review
- Distribution of Thrombophilia-Related Genetic Polymorphisms in Women with Reproductive Disorders.Biomedicines · 2026Article
- Postpartum maternal thrombophilia workup value in pregnancies with severe small for gestational age.Acta obstetricia et gynecologica Scandinavica · 2025Observational
- Even low levels of anticardiolipin antibodies are associated with pregnancy-related complications: A monocentric cohort study.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Antiphospholipid syndrome in pregnancy: a comprehensive literature review.BMC pregnancy and childbirth · 2025Review
- Impact of Systemic Lupus Erythematosus on Conception: Insights into Infertility, Fertility Preservation, Assisted Reproductive Technology, and Pregnancy Outcomes.Seminars in reproductive medicine · 2024Review
- [Obstetric Antiphospholipid Syndrome: Insights on the Diagnosis, Treatment, and Hot Issues].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Review
- Understanding the Pathophysiology of Preeclampsia: Exploring the Role of Antiphospholipid Antibodies and Future Directions.Journal of clinical medicine · 2024Review
- Thrombotic Markers in Pregnant Patients with and without SARS-CoV-2 Infection.American journal of perinatology · 2024Article
- Anti-Phospholipid Antibodies in Women with Placenta-Mediated Complications Delivered at >34 Weeks of Gestation.Journal of clinical medicine · 2023Article
- An advanced understanding of the heterogeneous clinical features of "non-criteria" obstetric antiphospholipid syndrome: Two case reports and a literature review.Frontiers in immunology · 2023Review
- Characterization of Vascular Patterns Associated with Endothelial Glycocalyx Damage in Early- and Late-Onset Preeclampsia.Biomedicines · 2022Article
- Pathogenesis, Diagnosis and Management of Obstetric Antiphospholipid Syndrome: A Comprehensive Review.Journal of clinical medicine · 2022Review
- Obstetric management of the most common autoimmune diseases: A narrative review.Frontiers in global women's health · 2022Review
- False-positive results of lupus anticoagulant tests should be kept in mind in pregnant patients receiving low molecular weight heparinJournal of the Turkish German Gynecological Association · 2021Article
- Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome.Circulation research · 2021Article
- Early-onset preeclampsia - The impact of antiphospholipid antibodies on disease severity.European journal of obstetrics, gynecology, and reproductive biology · 2021Article
- Anti-phospholipid antibodies in women presenting with preterm delivery because of preeclampsia or placental insufficiencyJournal of the Turkish German Gynecological Association · 2021Article
- Evaluation of the severe preeclampsia classification criterion for antiphospholipid syndrome in a study of 40 patients.Arthritis research & therapy · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Objective Preterm delivery for preeclampsia or placental insufficiency (PREPI) is a clinical criterion for antiphospholipid syndrome (APS), but no prior prospective studies have used the international classification criteria for APS. Our objective is to determine the proportion of women with PREPI who test positive for aPL using international criteria for antiphospholipid antibody (aPL) assays. Methods We conducted a prospective, case-control study of 148 women delivered < 36 weeks because of PREPI compared to 148 controls. PREPI cases delivered < 36 weeks were compared to matched controls. Cases and controls were tested for aPL. Demographic variables were compared with chi-squared and Wilcoxon-rank-sum statistics. Rates of + aPL were compared using adjusted odds ratios (aORs) for maternal body mass index (BMI) and Caucasian race. Positive aPL (+aPL) was defined as lupus anticoagulant (LA), anticardiolipin (aCL) immunoglobulin G (IgG) (GPL) or immunoglobulin M (IgM) (MPL) ≥ 40, or anti-β2-glycoprotein I (aβ2GPI) IgG (SGU) or IgM (SMU) ≥ 40. Results Controls were more likely to be Caucasian (87% vs 70%, p = 0.006) and had lower BMIs (BMI 26 vs 33, p < 0.001). Positive aPL were found more commonly in cases than controls (11.5% vs 1.4%, aOR 8.9 (95% CI 1.9-41.4)). In + aPL cases, 76% had + LA, 41% had + aCL, and 24% had + aβ2GPI. Conclusion Women requiring early delivery for PREPI are more likely to have aPL (and thus APS) than controls. This is the first prospective study using both obstetric definitions and laboratory criteria in accordance with APS international criteria.
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Registered trials
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