ArticleVirulence2018
Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus.
Article in Virulence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Functional Analysis ofJournal of fungi (Basel, Switzerland) · 2025Article
- The Role ofInternational journal of molecular sciences · 2025Article
- Key sugar transporters drive development and pathogenicity inFrontiers in cellular and infection microbiology · 2025Article
- Evolution of the pathogenic moldmSphere · 2024Article
- The Autophagy-Related Protein ATG8 Orchestrates Asexual Development and AFB1 Biosynthesis inJournal of fungi (Basel, Switzerland) · 2024Article
- Insights into copper sensing and tolerance inFrontiers in microbiology · 2024Article
- Functional characterization of genes encoding cadmium pumping PMicrobiology spectrum · 2023Article
- Identification and Characterization of the Determinants of Copper Resistance in the Acidophilic FungusApplied and environmental microbiology · 2023Article
- Genomic and Phenotypic Trait Variation of the Opportunistic Human Pathogen Aspergillus flavus and Its Close Relatives.Microbiology spectrum · 2022Article
- Enhanced Hemolytic Activity of MesophilicMicroorganisms · 2022Article
- Phosphoglucose Isomerase Plays a Key Role in Sugar Homeostasis, Stress Response, and Pathogenicity inFrontiers in cellular and infection microbiology · 2021Article
- Article
- Transcriptome Sequencing Revealed an Inhibitory Mechanism ofInternational journal of molecular sciences · 2020Article
- Gas Chromatography-Mass Spectrometry Profiling of Volatile Compounds Reveals Metabolic Changes in a Non-AflatoxigenicToxins · 2020Article
- New insights into copper homeostasis in filamentous fungi.International microbiology : the official journal of the Spanish Society for Microbiology · 2020Review
- Copper Tolerance Mediated byFrontiers in microbiology · 2020Article
- Copper Utilization, Regulation, and Acquisition byInternational journal of molecular sciences · 2019Review
- Cinnamaldehyde, a Promising Natural Preservative AgainstFrontiers in microbiology · 2019Article
- Copper Homeostasis inFrontiers in microbiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ubiquitous fungus Aspergillus flavus is notorious for contaminating many important crops and food-stuffs with the carcinogenic mycotoxin, aflatoxin. This fungus is also the second most frequent Aspergillus pathogen after A. fumigatus infecting immunosuppressed patients. In many human fungal pathogens including A. fumigatus, the ability to defend from toxic levels of copper (Cu) is essential in pathogenesis. In A. fumigatus, the Cu-fist DNA binding protein, AceA, and the Cu ATPase transporter, CrpA, play critical roles in Cu defense. Here, we show that A. flavus tolerates higher concentrations of Cu than A. fumigatus and other Aspergillus spp. associated with the presence of two homologs of A. fumigatus CrpA termed CrpA and CrpB. Both crpA and crpB are transcriptionally induced by increasing Cu concentrations via AceA activity. Deletion of crpA or crpB alone did not alter high Cu tolerance, suggesting they are redundant. Deletion of both genes resulted in extreme Cu sensitivity that was greater than that following deletion of the regulatory transcription factor aceA. The ΔcrpAΔcrpB and ΔaceA strains were also sensitive to ROI stress. Compared to wild type, these mutants were impaired in the ability to colonize maize seed treated with Cu fungicide but showed no difference in virulence on non-treated seed. A mouse model of invasive aspergillosis showed ΔcrpAΔcrpB and to a lesser degree ΔaceA to be significantly reduced in virulence, following the greater sensitivity of ΔcrpAΔcrpB to Cu than ΔaceA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.