ArticleAnnals of laboratory medicine2018
Detection of mcr-1 Plasmids in Enterobacteriaceae Isolates From Human Specimens: Comparison With Those in Escherichia coli Isolates From Livestock in Korea.
Article in Annals of laboratory medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 28 citations in OpenAlex.
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- Antibiotic resistance and β-lactam resistant genes among bacterial isolates from clinical, river water and poultry samples from Kathmandu, Nepal.JAC-antimicrobial resistance · 2025Article
- High prevalence ofApplied and environmental microbiology · 2025Article
- Case Report: Transferable IncX4 plasmid carryingFrontiers in veterinary science · 2025Article
- Alteration in the Morphological and Transcriptomic Profiles ofMicroorganisms · 2024Article
- A Review of Resistance to Polymyxins and Evolving Mobile Colistin Resistance Gene (Antibiotics (Basel, Switzerland) · 2023Review
- Worldwide Prevalence ofPathogens (Basel, Switzerland) · 2022Review
- Prevalence and Molecular Epidemiology of Extended-Spectrum-β-Lactamase (ESBL)-ProducingAnnals of laboratory medicine · 2021Article
- Molecular Epidemiology of Extensively Drug-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Mobile Colistin Resistance GeneMicroorganisms · 2021Article
- Article
- Comparative Genome Analysis of Livestock and Human Colistin-ResistantInfection and drug resistance · 2021Article
- Prevalence and Genetic Characterization ofJournal of microbiology and biotechnology · 2020Article
- Identification of an extensively drug-resistant Escherichia coli clinical strain harboring mcr-1 and blaThe Journal of antibiotics · 2020Article
- First Report of anAntibiotics (Basel, Switzerland) · 2020Article
- Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance.Membranes · 2020Review
- Overview of Evidence of Antimicrobial Use and Antimicrobial Resistance in the Food Chain.Antibiotics (Basel, Switzerland) · 2020Review
- Plasmid mediated colistin resistantGut pathogens · 2020Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe emerging mobile colistin resistance gene, mcr-1, is an ongoing worldwide concern and an evaluation of clinical isolates harboring this gene is required in Korea. We investigated mcr-1-possessing Enterobacteriaceae among Enterobacteriaceae strains isolated in Korea, and compared the genetic details of the plasmids with those in Escherichia coli isolates from livestock.
methodsAmong 9,396 Enterobacteriaceae clinical isolates collected between 2010 and 2015, 1,347 (14.3%) strains were resistant to colistin and those were screened for mcr-1 by PCR. Colistin minimum inhibitory concentrations (MICs) were determined by microdilution, and conjugal transfer of the mcr-1-harboring plasmids was assessed by direct mating. Whole genomes of three mcr-1-positive Enterobacteriaceae clinical isolates and 11 livestock-origin mcr-1-positive E. coli isolates were sequenced.
resultsTwo E. coli and one Enterobacter aerogenes clinical isolates carried carried IncI2 plasmids harboring mcr-1, which conferred colistin resistance (E. coli MIC, 4 mg/L; E. aerogenes MIC, 32 mg/L). The strains possessed the complete conjugal machinery except for E. aerogenes harboring a truncated prepilin peptidase. The E. coli plasmid transferred more efficiently to E. coli than to Klebsiella pneumoniae or Enterobacter cloacae recipients. Among the three bacterial hosts, the colistin MIC was the highest for E. coli owing to the higher mcr-1-plasmid copy number and mcr-1 expression levels. Ten mcr-1-positive chicken-origin E. coli strains also possessed mcr-1-harboring IncI2 plasmids closely related to that in the clinical E. aerogenes isolate, and the remaining one porcine-origin E. coli possessed an mcr-1-harboring IncX4 plasmid.
conclusionsmcr-1-harboring IncI2 plasmids were identified in clinical Enterobacteriaceae isolates. These plasmids were closely associated with those in chicken-origin E. coli strains in Korea, supporting the concept of mcr-1 dissemination between humans and livestock.
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