ArticleAnnals of laboratory medicine2018
Complete Blood Count Reference Intervals and Patterns of Changes Across Pediatric, Adult, and Geriatric Ages in Korea.
Article in Annals of laboratory medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Hematological parameters' reference intervals in apparently healthy individuals in Saudi Arabia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Prevalence and potential associations of the 2022 newly introduced monocyte value for diagnosis of chronic myelomonocytic leukemia in a general Austrian population.Wiener medizinische Wochenschrift (1946) · 2026Article
- Defining Reference Intervals for Complete Blood Count and Micronutrient Parameters in Urban Bangladeshi Population.Biomolecules · 2026Article
- Myeloid Cell Function and Cytokine Profiles in Paediatric Haemophilia A: Insights From FVIII and Emicizumab Prophylaxis.Journal of cellular and molecular medicine · 2026Article
- Hierarchical organ aging signatures from routine abdominal CT add incremental disease risk stratification beyond blood biomarkers.medRxiv : the preprint server for health sciences · 2026Article
- Reference Values for Extended Lymphocyte Subsets in Korean Children: A Multicenter Study Using the EuroFlow PIDOT Panel.Annals of laboratory medicine · 2026Article
- Personalized Interpretation of CBC and the Role of CRP in Early Detection and Monitoring of Blood Infection or Sepsis: A Diagnostic Perspective.Health science reports · 2026Article
- Alterations and predictive potential of haematological parameters in paediatric tuberculosis and non-tuberculous mycobacterial disease.BMC infectious diseases · 2026Article
- Evaluation of regional differences, age, and sex variations in hematological parameters among adolescents in Sudan: a multicenter community-based cross-sectional study.Frontiers in pediatrics · 2026Article
- A Machine Learning Approach to Reference Interval Estimation for Red Cell Parameters in a South and East Asian Population.Annals of laboratory medicine · 2026Article
- Article
- Reference Intervals for Hematological Inflammatory Ratios in Healthy Dogs.Animals : an open access journal from MDPI · 2025Article
- Physiological Changes and Trimester-Specific Reference Intervals for Complete Blood Count Parameters in Korean Pregnant Women.Medicina (Kaunas, Lithuania) · 2025Article
- Hematological Inflammatory Markers Across Neurodevelopmental Disorders: Preliminary Findings of an Observational Retrospective Study.Brain sciences · 2025Article
- Accuracy of Red Blood Cell Parameters in Predicting αJournal of clinical medicine · 2025Article
- Exploring sex-specific hematological changes and their impact on quality of life in patients with prolactinoma.Pituitary · 2025Article
- Biological aging of different blood cell types.GeroScience · 2025Article
- Monocyte STAT1 phosphorylation and treatment response of JAK inhibitors in chronic nonbacterial osteomyelitis.Pediatric rheumatology online journal · 2025Article
- Article
- Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSampling a healthy reference population to generate reference intervals (RIs) for complete blood count (CBC) parameters is not common for pediatric and geriatric ages. We established age- and sex-specific RIs for CBC parameters across pediatric, adult, and geriatric ages using secondary data, evaluating patterns of changes in CBC parameters.
methodsThe reference population comprised 804,623 health examinees (66,611 aged 3-17 years; 564,280 aged 18-59 years; 173,732 aged 60-99 years), and, we excluded 22,766 examinees after outlier testing. The CBC parameters (red blood cell [RBC], white blood cell [WBC], and platelet parameters) from 781,857 examinees were studied. We determined statistically significant partitions of age and sex, and calculated RIs according to the CLSI C28-A3 guidelines.
resultsRBC parameters increased with age until adulthood and decreased with age in males, but increased before puberty and then decreased with age in females. WBC and platelet counts were the highest in early childhood and decreased with age. Sex differences in each age group were noted: WBC count was higher in males than in females during adulthood, but platelet count was higher in females than in males from puberty onwards (P<0.001). Neutrophil count was the lowest in early childhood and increased with age. Lymphocyte count decreased with age after peaking in early childhood. Eosinophil count was the highest in childhood and higher in males than in females. Monocyte count was higher in males than in females (P<0.001).
conclusionsWe provide comprehensive age- and sex-specific RIs for CBC parameters, which show dynamic changes with both age and sex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.