Evidence map›Paper›PMID 30027513›Full record

ArticleClinical pharmacokinetics2018

Comment on "Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials".

Joseph F Standing, Brian J Anderson, Stefanie Hennig, Nick H Holford, Trevor N Johnston, Catherijne A J Knibbe, Dagan O Lonsdale, Amin Rostami-Hodjegan

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Clinical pharmacokinetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Joseph F StandingUCL Great Ormond Street Institute for Child Health, Room 661, London, WC1N 1EH, UK. j.standing@ucl.ac.uk.
Brian J AndersonDepartment of Anaesthesia, University of Auckland, Auckland, New Zealand.
Stefanie HennigSchool of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.
Nick H HolfordDepartment of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.
Trevor N JohnstonCertara UK Limited, Simcyp Division, Sheffield, UK.
Catherijne A J KnibbeDivision of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, University of Leiden, Leiden, The Netherlands.
Dagan O LonsdaleDepartment of Clinical Pharmacology, Institute for Infection and Immunity, St George's University of London, London, UK.
Amin Rostami-HodjeganCentre for Applied Pharmacokinetic Research (CAPKR), University of Manchester, Manchester, UK.

Funding

Medical Research Council MR/M008665/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnticonvulsantsLamotrigineAge FactorsHumansTriazinesAnticonvulsantsLamotrigineTriazines

Identifiers

PMID30027513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.