ReviewCurrent genetics2019
Genomes shed light on the secret life of Candida glabrata: not so asexual, not so commensal.
Review in Current genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- Genetic Tools in the Nakaseomyces clade for Evolutionary Comparisons of Signal Transduction Pathways.Yeast (Chichester, England) · 2026Article
- Distinct properties of human pathogenicmSystems · 2026Article
- An update on clinically relevant, rare, and emergingClinical microbiology reviews · 2025Review
- Genome analysis and machine learning-based feature selection strategy reveal potential drug-resistance determinants inEmerging microbes & infections · 2025Article
- Induction of Antifungal Tolerance Reveals Genetic and Phenotypic Changes inJournal of fungi (Basel, Switzerland) · 2025Article
- From crops to clinic: the impact of dual azole use on antifungal resistance inFrontiers in microbiology · 2025Review
- Prevalence, drug resistance and genetic diversity ofMycology · 2025Article
- Threats from theMicrobiology and molecular biology reviews : MMBR · 2024Review
- Microbe Profile:Microbiology (Reading, England) · 2024Review
- Candida species-specific colonization in the healthy and impaired human gastrointestinal tract as simulated using the Mucosal Ileum-SHIME® model.FEMS microbiology ecology · 2024Article
- Regulation of thiamine and pyruvate decarboxylase genes by Pdc2 in Nakaseomyces glabratus (Candida glabrata) is complex.G3 (Bethesda, Md.) · 2024Article
- Decoding the role of oxidative stress resistance and alternative carbon substrate assimilation in the mature biofilm growth mode of Candida glabrata.BMC microbiology · 2024Article
- Article
- Changes in fungal taxonomy: mycological rationale and clinical implications.Clinical microbiology reviews · 2023Review
- Origin of fungal hybrids with pathogenic potential from warm seawater environments.Nature communications · 2023Article
- Pyruvate decarboxylase and thiamine biosynthetic genes are regulated differently by Pdc2 in S. cerevisiae and C. glabrata.PloS one · 2023Article
- Genomic Assembly of Clinical Candida glabrata (Nakaseomyces glabrata) Isolates Reveals within-Species Structural Plasticity and Association withMicrobiology spectrum · 2022Article
- Ploidy Variation and Spontaneous Haploid-Diploid Switching of Candida glabrata Clinical Isolates.mSphere · 2022Article
- Article
- Collateral consequences of agricultural fungicides on pathogenic yeasts: A One Health perspective to tackle azole resistance.Mycoses · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Candida glabrata is an opportunistic yeast pathogen, whose incidence has increased over the last decades. Despite its genus name, this species is actually more closely related to the budding yeast Saccharomyces cerevisiae than to other Candida pathogens, such as Candida albicans. Hence, C. glabrata and C. albicans must have acquired the ability to infect humans independently, which is reflected in the use of different mechanism for virulence, and survival in the host. Yet, research on C. glabrata suffers from assumptions carried over from the more studied C. albicans. Regarding the adaptation of C. glabrata to the human host, the prejudice was that, just as C. albicans, C. glabrata is a natural human commensal that turns deadly when immune defenses weaken. It was also considered asexual, as no one has observed mating, diploids, or spores, despite great efforts. However, the recent analysis of whole genomes from globally distributed C. glabrata isolates have shaken these assumptions. C. glabrata seems to be only secondarily associated to humans, as indicated by a lack of co-evolution with its host, and genomic footprints of recombination shows compelling evidence that this yeast is able to have sex. Here, we discuss the implications of this and other recent findings and highlight the new questions opened by this change in paradigm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.