ArticleMolecular genetics and genomics : MGG2018
The evolution of three siderophore biosynthetic clusters in environmental and host-associating strains of Pantoea.
Article in Molecular genetics and genomics : MGG, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Comparative genomics ofMicrobial genomics · 2026Article
- Comparative genomic insights into the genus Pantoea: genetic determinants of ecological lifestyle diversity and plant growth-promoting potential.World journal of microbiology & biotechnology · 2026Article
- Forging the iron-net: Towards a quantitative understanding of microbial communities via siderophore-mediated interactions.Quantitative biology (Beijing, China) · 2025Article
- Implications of bacteria‒bacteria interactions within the plant microbiota for plant health and productivity.Journal of Zhejiang University. Science. B · 2024Review
- Article
- Catechol siderophores framed on 2,3-dihydroxybenzoyl-L-serine fromFrontiers in microbiology · 2023Article
- Bacterial Siderophores: Classification, Biosynthesis, Perspectives of Use in Agriculture.Plants (Basel, Switzerland) · 2022Review
- Comparative genomics to examine the endophytic potential of Pantoea agglomerans DAPP-PG 734.BMC genomics · 2022Article
- Negatively Regulated Aerobactin and Desferrioxamine E by Fur in Pantoea ananatis Are Required for Full Siderophore Production and Antibacterial Activity, but Not for Virulence.Applied and environmental microbiology · 2022Article
- The Integration of Genome Mining, Comparative Genomics, and Functional Genetics for Biosynthetic Gene Cluster Identification.Frontiers in genetics · 2020Article
- Antimicrobial Activity Against Phytopathogens and Inhibitory Activity on Solanine in Potatoes of the Endophytic Bacteria Isolated From Potato Tubers.Frontiers in microbiology · 2020Article
- Comparison of five bacterial strains producing siderophores with ability to chelate iron under alkaline conditions.AMB Express · 2019Article
- Bacterial Metabolites Produced Under Iron Limitation Kill Pinewood Nematode and AttractFrontiers in microbiology · 2019Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
For many pathogenic members of the Enterobacterales, siderophores play an important role in virulence, yet the siderophores of the host-associating members of the genus Pantoea remain unexplored. We conducted a genome-wide survey of environmental and host-associating strains of Pantoea to identify known and candidate siderophore biosynthetic clusters. Our analysis identified three clusters homologous to those of enterobactin, desferrioxamine, and aerobactin that were prevalent among Pantoea species. Using both phylogenetic and comparative genomic approaches, we demonstrate that the enterobactin-like cluster was present in the common ancestor of all Pantoea, with evidence for three independent losses of the cluster in P. eucalypti, P. eucrina, and the P. ananatis-P. stewartii lineage. The desferrioxamine biosynthetic cluster, previously described and characterized in Pantoea, was horizontally acquired from its close relative Erwinia, with phylogenetic evidence that these transfer events were ancient and occurred between ancestral lineages. The aerobactin cluster was identified in three host-associating species groups, P. septica, P. ananatis, and P. stewartii, with strong evidence for horizontal acquisition from human-pathogenic members of the Enterobacterales. Our work identifies and describes the key siderophore clusters in Pantoea, shows three distinct evolutionary processes driving their diversification, and provides a foundation for exploring the roles that these siderophores may play in human opportunistic infections.
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