Evidence map›Paper›PMID 30027299›Full record

ArticleImmunogenetics2018

IPD-MHC: nomenclature requirements for the non-human major histocompatibility complex in the next-generation sequencing era.

Giuseppe Maccari, James Robinson, Ronald E Bontrop, Nel Otting, Natasja G de Groot, Chak-Sum Ho, Keith T Ballingall, Steven G E Marsh, John A Hammond

Open access · hybridAbstract read
In one paragraph

Article in Immunogenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Giuseppe MaccariThe Pirbright Institute, Woking, Surrey, UK.
James RobinsonAnthony Nolan Research Institute, London, UK.
Ronald E BontropBiomedical Primate Research Centre, Rijswijk, The Netherlands.
Nel OttingBiomedical Primate Research Centre, Rijswijk, The Netherlands.
Natasja G de GrootBiomedical Primate Research Centre, Rijswijk, The Netherlands.
Chak-Sum HoGift of Life Michigan, Ann Arbor, MI, USA.
Keith T BallingallMoredun Research Institute, Midlothian, UK.
Steven G E MarshAnthony Nolan Research Institute, London, UK.
John A HammondThe Pirbright Institute, Woking, Surrey, UK. john.hammond@pirbright.ac.uk.
Biomedical Primate Research Centre · NLThe Pirbright Institute · GBUniversity College London · GBGift of Life Michigan · USMoredun Research Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M011488/1Biotechnology and Biological Sciences Research Council BBS/E/I/00001710Biotechnology and Biological Sciences Research Council BBS/E/I/00007030Biotechnology and Biological Sciences Research Council BBS/E/I/00007038
6 · The paper itself

Abstract

The IPD-MHC Database is the official repository for non-human MHC sequences, overseen and supported by the Comparative MHC Nomenclature Committee, providing access to curated MHC data and associated analysis tools. To address the increasing amount and complexity of data being submitted, an entirely upgraded version of the IPD-MHC Database was recently released to maintain IPD-MHC as the central platform for the comparison of curated MHC data. As a consequence, a new level of nomenclature standardisation is required between the different species to enable data submission and to allow the unambiguous inter- and intra-species comparison of alleles. However, any changes must retain the flexibility demanded by the unique biology of different taxonomic groups. Here, we describe the rationale for a standardised nomenclature system and summarise the changes that have been driven by the requirements of implementing the IPD-MHC database. This modified nomenclature system is essential to maintain the current functionality of IPD-MHC and provide a scalable future-proof database organisation to fully exploit the bioinformatic tools used for analysis.

Indexed as

Databases, GeneticAllelesAnimalsCattleComputational BiologyHigh-Throughput Nucleotide SequencingHistocompatibility AntigensHumansMajor Histocompatibility ComplexSheepHistocompatibility AntigensComparative MHCDatabaseIPD-MHCMHCNomenclatureVariation

Identifiers

PMID30027299
PMCPMC6182402
OpenAlexW2883827655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.