Evidence map›Paper›PMID 30027145›Full record

ArticleInternational journal of reproductive biomedicine2018

Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT.

Soheila Arefi, Elham Fazeli, Manijeh Esfahani, Nasim Borhani, Nazila Yamini, Ahmad Hosseini, Fattaneh Farifteh

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of reproductive biomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04998279 (Intrauterine Infusion of Granulocyte Colony Stimulating Factor and Reproductive Outcomes in Infertile Women with History of Recurrent Implantation Failure), which is not on this map. Cited by 20 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 7 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04998279 completednot on this mapstarted 2019, after this paper: background citation

Intrauterine Infusion of Granulocyte Colony Stimulating Factor and Reproductive Outcomes in Infertile Women with History of Recurrent Implantation Failure

TypeobservationalSponsorCairo UniversityRan2019 to 2024Enrolled100ConditionsRecurrent Implantation Failure, Granulocyte Colony-Stimulating Factor, InfertilityArmsGranulocyte Colony-Stimulating Factor, placebo
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 7 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Soheila ArefiGenetics and In Vitro Assisted Reproductive (GIVAR) Center, Erfan Hospital, Tehran, Iran.
Elham FazeliDepartment of Anatomy and Reproductive Biology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Manijeh EsfahaniGenetics and In Vitro Assisted Reproductive (GIVAR) Center, Erfan Hospital, Tehran, Iran.
Nasim BorhaniSchool of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Nazila YaminiIVF Center, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Ahmad HosseiniGenetics and In Vitro Assisted Reproductive (GIVAR) Center, Erfan Hospital, Tehran, Iran.
Fattaneh FariftehGenetics and In Vitro Assisted Reproductive (GIVAR) Center, Erfan Hospital, Tehran, Iran.
Isfahan Fertility and Infertility Center · IRAcademic Center for Education, Culture and Research · IRShahid Beheshti University of Medical Sciences · IRShahroud University of Medical Sciences · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFamily of colony-stimulating factors (CSF) have an essential role on early cross talk between embryo and uterine endometrium.

objectiveThe aim of this study was to evaluate the effects of the single dose of Granulocyte-CSF (G-CSF) injection on clinical outcome of assisted reproductive technology cycle in patients with repeated implantation failures. MATERIALS AND

methodsThis randomized control trial study was performed on 52 infertile women who referred to the clinic with the history of more than three previous In vitro fertilization/Intracytoplasmic sperm injection-embryo transfer failures. All patients were stimulated with standard long protocol. All embryos were transferred on day five in blastocyst stage in both groups. The treated group received 300 µg (0.5 ml) recombinant human G-CSF subcutaneously which was injected 30 min before blastocyst embryo transfer.

resultsThere was not statistically significant differences in abortion rate in G-CSF and control group (p=0.09). G-CSF treated group showed higher clinical pregnancy rate in comparison with control group (56.2% vs. 40.0%) but it was not statistically significant (p=0.09). Although live birth rate in G-CSF group was higher than control group (53.1% vs. 35.0%) but there wasn't statistically significant difference in the overall live birth rate between the two groups (p=0.10). G-CSF group had a twin pregnancies while in control group there was no twin pregnancy.

conclusionOur result demonstrates the possibility that pregnancy outcome is better in women with repeated unexplained In vitro fertilization failure who are treated with G-CSF.

Indexed as

Assisted reproductive technologyEmbryo implantationGranulocyte colony-stimulating factorPregnancy ratesRandomized controlled trial

Identifiers

PMID30027145
PMCPMC6046207
OpenAlexW2810265265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.