Evidence map›Paper›PMID 30027037›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2018

Novel Intrapolymerization Doped Manganese-Eumelanin Coordination Nanocomposites with Ultrahigh Relaxivity and Their Application in Tumor Theranostics.

Heng Liu, Chengchao Chu, Yu Liu, Xin Pang, Yayun Wu, Zijian Zhou, Pengfei Zhang, Weiguo Zhang, Gang Liu, Xiaoyuan Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Functionalization of and through Melanin: Strategies and Bio-Applications.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Melanin-Like Nanomedicine in Photothermal Therapy Applications.International journal of molecular sciences · 2021
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Cytomembrane-Mediated Transport of Metal Ions with Biological Specificity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Article
  19. Functional probes for cardiovascular molecular imaging.Quantitative imaging in medicine and surgery · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heng LiuDepartment of Radiology the Third Affiliated Hospital Army Medical University Chongqing 400010 China.ORCID 0000-0002-1238-0683
Chengchao ChuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China.
Yu LiuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China.
Xin PangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China.
Yayun WuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China.
Zijian ZhouState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China.
Pengfei ZhangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China.
Weiguo ZhangDepartment of Radiology the Third Affiliated Hospital Army Medical University Chongqing 400010 China.
Gang LiuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China.
Xiaoyuan ChenLaboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda MD 20892 USA.

Funding

Laboratory of Molecular Imaging and NanomedicineZIAEB000073 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI CHEN, XIAOYUAN · 2010 to 2020
$32.8M
6 · The paper itself

Abstract

While magnetic resonance imaging contrast agents have potential in noninvasive image-guided tumor treatment, further developments are needed to increase contrast, biodegradability, and safety. Here, novel engineered manganese-eumelanin coordination nanocomposites (MnEMNPs) are developed via a facile one-pot intrapolymerization doping (IPD) approach in aqueous solution, through simple chemical oxidation-polymerization of the 3,4-dihydroxy-DL-phenylalanine precursor with potassium permanganate serving as the Mn source and an oxidant. The resulting MnEMNPs possess ultrahigh longitudinal relaxivity (

Indexed as

eumelaningeometrical confinementmagnetic resonance imagingmanganesetheranostics

Identifiers

PMID30027037
PMCPMC6051206

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.