ArticleVirus evolution2018
A complex mosaic of enteroviruses shapes community-acquired hand, foot and mouth disease transmission and evolution within a single hospital.
Article in Virus evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Historical evolution, research hotspots and emerging trends of pediatric hand, foot, and mouth disease: a bibliometric worldview since the 21st century.Frontiers in medicine · 2025Pooled it
- Preliminary Genetic Characterization of Enteroviruses in Pediatric HFMD Cases: First Data from Jeddah, Saudi Arabia.Journal of epidemiology and global health · 2025Article
- Article
- Coxsackievirus A6 U.K. Genetic and Clinical Epidemiology Pre- and Post-SARS-CoV-2 Emergence.Pathogens (Basel, Switzerland) · 2024Article
- Genetic diversity and spread of recombinant coxsackievirus A4 in hand, foot, and mouth disease cases in Bangkok, Thailand: 2017-2023.Scientific reports · 2024Article
- Changing Epidemiology of Hand, Foot, and Mouth Disease Causative Agents and Contributing Factors.The American journal of tropical medicine and hygiene · 2024Review
- A review of the recombination events, mechanisms and consequences of Coxsackievirus A6.Infectious medicine · 2024Review
- Article
- Molecular epidemiology of enteroviruses associated with hand, foot, and mouth disease in South India from 2015 to 2017.Archives of virology · 2022Article
- Reclaiming independence in spatial-clustering datasets: A series of data-driven spatial weights matrices.Statistics in medicine · 2022Article
- Article
- Identification of missed viruses by metagenomic sequencing of clinical respiratory samples from Kenya.Scientific reports · 2022Article
- Analysis of miRNAs Involved in Mouse Heart Injury Upon Coxsackievirus A2 Infection.Frontiers in cellular and infection microbiology · 2022Article
- Next generation sequencing of human enterovirus strains from an outbreak of enterovirus A71 shows applicability to outbreak investigations.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020Article
- Emerging recombination of the C2 sub-genotype of HFMD-associated CV-A4 is persistently and extensively circulating in China.Scientific reports · 2019Article
- High Permissiveness for Genetic Exchanges between Enteroviruses of Species A, including Enterovirus 71, Favors Evolution through Intertypic Recombination in Madagascar.Journal of virology · 2019Article
- A neonatal murine model of coxsackievirus A4 infection for evaluation of vaccines and antiviral drugs.Emerging microbes & infections · 2019Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human enteroviruses (EV) pose a major risk to public health. This is especially so in the Asia-Pacific region where increasing numbers of hand, foot and mouth disease (HFMD) cases and large outbreaks of severe neurological disease associated with EV-A71 have occurred. Despite their importance, key aspects of the emergence, epidemiology and evolution of EVs remain unclear, and most studies of EV evolution have focused on a limited number of genes. Here, we describe the genomic-scale evolution of EV-A viruses sampled from pediatric patients with mild disease attending a single hospital in western Sydney, Australia, over an 18-month period. This analysis revealed the presence of eight viral serotypes-Coxsackievirus (CV) A2, A4, A5, A6, A8, A10, A16 and EV-A71-with up to four different serotypes circulating in any 1 month. Despite an absence of large-scale outbreaks, high levels of geographical and temporal mixing of serotypes were identified. Phylogenetic analysis revealed that multiple strains of the same serotype were present in the community, and that this diversity was shaped by multiple introductions into the Sydney population, with only a single lineage of CV-A6 exhibiting
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