Evidence map›Paper›PMID 30026857›Full record

ArticleJournal of Cancer2018

Long non-coding RNA CRYBG3 regulates glycolysis of lung cancer cells by interacting with lactate dehydrogenase A.

Huaiyuan Chen, Hailong Pei, Wentao Hu, Ji Ma, Jian Zhang, Weidong Mao, Jing Nie, Chao Xu, Bingyan Li, Tom K Hei and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
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  14. Noncoding RNAs: the shot callers in tumor immune escape.Signal transduction and targeted therapy · 2020
    Review
  15. Article
  16. Non-Coding RNAs in Lung Tumor Initiation and Progression.International journal of molecular sciences · 2020
    Review
  17. Article
  18. Review
  19. Whole-exome sequencing indicatesExperimental biology and medicine (Maywood, N.J.) · 2019
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Huaiyuan ChenSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Hailong PeiSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Wentao HuSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Ji MaSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Jian ZhangSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Weidong MaoSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Jing NieSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Chao XuSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Bingyan LiMedical College of Soochow University, Suzhou 215123, China.
Tom K HeiSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Chang WangSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Guangming ZhouSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
Soochow University · CNColumbia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells usually utilize glucose as a carbon source for aerobic glycolysis, a phenomenon known as the Warburg effect. And a high rate of glycolysis has been observed in lung cancer cells. The growing evidence indicates that long non-coding RNAs (lncRNAs) are important players in lung cancer initiation and progression. However, the correlation between lncRNAs and glycolysis remains unclear. In this study, we recognized a lncRNA, LNC CRYBG3, which can interact with lactate dehydrogenase A (LDHA), a vital enzyme of glycolysis, is highly upregulated in both clinical lung cancer tissues and

Indexed as

GlycolysisLactateLDHALNC CRYBG3Lung cancerPyruvate

Identifiers

PMID30026857
PMCPMC6036897
OpenAlexW2828785843

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.