Evidence map›Paper›PMID 30026855›Full record

ArticleJournal of Cancer2018

ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker.

Toshie Yoneyama, Michael Gorry, Andrea Sobo-Vujanovic, Yan Lin, Lazar Vujanovic, Autumn Gaither-Davis, Marcia L Moss, Miles A Miller, Linda G Griffith, Douglas A Lauffenburger and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 41 citations in OpenAlex.

  1. Proteomic profiling of CD133 + and CD326 + (EpCAM) subpopulations in A549 cells: insights into pluripotency and tumor heterogeneity.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  3. International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Toshie YoneyamaDepartment of Pathology, University of Pittsburgh; UPMC Hillman Cancer Center, Pittsburgh, PA.
Michael GorryDepartment of Pathology, University of Pittsburgh; UPMC Hillman Cancer Center, Pittsburgh, PA.
Andrea Sobo-VujanovicDepartment of Pathology, University of Pittsburgh; UPMC Hillman Cancer Center, Pittsburgh, PA.
Yan LinDepartment of Biostatistics, University of Pittsburgh; UPMC Hillman Cancer Center, Pittsburgh, PA.
Lazar VujanovicDepartment of Medicine, University of Pittsburgh; UPMC Hillman Cancer Center, Pittsburgh, PA.
Autumn Gaither-DavisDepartment of Medicine, University of Pittsburgh; UPMC Hillman Cancer Center, Pittsburgh, PA.
Marcia L MossBioZyme Inc, Apex, NC.
Miles A MillerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.
Linda G GriffithCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Douglas A LauffenburgerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.
Laura P StabileDepartment of Pharmacology and Chemical Biology, University of Pittsburgh; UPMC Hillman Cancer Center, Pittsburgh, PA.
James HermanDepartment of Medicine, University of Pittsburgh; UPMC Hillman Cancer Center, Pittsburgh, PA.
Nikola L VujanovicDepartment of Pathology, University of Pittsburgh; UPMC Hillman Cancer Center, Pittsburgh, PA.
VA Pittsburgh Healthcare System · USCenter for Systems Biology · USHarvard University · USMassachusetts Institute of Technology · US

Funding

Engineered Antibody EGFR Antagonist Cancer TherapeuticsR01CA096504 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WITTRUP, KARL DANE · 2002 to 2017
$9.7M
Single Cell In Vivo Imaging Technology to Analyze Taxane Nano Formulations in Breast CancerR00CA207744 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, MILES A · 2018 to 2020
$747k
Defining ADAM Sheddase Activities as Lung Cancer BiomarkersI01BX000993 · VA · VETERANS HEALTH ADMINISTRATION · PI VUJANOVIC, NIKOLA LAZAR · 2013 to 2015
–
BLRD VA I01 BX000993NCI NIH HHS R00 CA207744NCI NIH HHS R01 CA096504
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ADAM10ADAM17Blood exosomesCancer biomarkerFluorogenic peptide substrateLung cancerLysateProteolytic activity matrix analysisSheddase activityTumor tissue

Identifiers

PMID30026855
PMCPMC6036891
OpenAlexW2866326875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.